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XB-ART-27824
Neurosci Lett 1987 Dec 16;831-2:89-94. doi: 10.1016/0304-3940(87)90221-7.
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Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane.

Reale V , Ashford ML , Barnard EA .


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Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is dose-dependent, with a threshold near 10(-9)M VIP. The effect is potentiated by forskolin. Of several other types of neuropeptide tested, only avian pancreatic polypeptide gives a response: this is similar to that of VIP, but this peptide can also potentiate the response to VIP.

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Species referenced: Xenopus laevis
Genes referenced: vip