XB-ART-24150
Dev Immunol
1992 Jan 01;21:1-6. doi: 10.1155/1992/28568.
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Changes in the amphibian antibody repertoire are correlated with metamorphosis and not with age or size.
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Tadpole and adult Xenopus, manipulated to be of comparable size, exhibited stage-specific antibody expression. The production of adult-type higher-affinity anti-DNP antibodies proved to be independent of the age and size of the individual and is concomitant with the completion of metamorphosis. The appearance of new antibody specificities at such a time suggests that their expression occurs with the cell turnover and renewal during a period of morphological changes.
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