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Proc Natl Acad Sci U S A
2010 Aug 24;10734:15264-8. doi: 10.1073/pnas.1006393107.
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A mammalian neural tissue opsin (Opsin 5) is a deepbrain photoreceptor in birds.
Nakane Y
,
Ikegami K
,
Ono H
,
Yamamoto N
,
Yoshida S
,
Hirunagi K
,
Ebihara S
,
Kubo Y
,
Yoshimura T
.
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It has been known for many decades that nonmammalian vertebrates detect light by deepbrain photoreceptors that lie outside the retina and pineal organ to regulate seasonal cycle of reproduction. However, the identity of these photoreceptors has so far remained unclear. Here we report that Opsin 5 is a deepbrain photoreceptive molecule in the quail brain. Expression analysis of members of the opsin superfamily identified as Opsin 5 (OPN5; also known as Gpr136, Neuropsin, PGR12, and TMEM13) mRNA in the paraventricular organ (PVO), an area long believed to be capable of phototransduction. Immunohistochemistry identified Opsin 5 in neurons that contact the cerebrospinal fluid in the PVO, as well as fibers extending to the external zone of the median eminence adjacent to the pars tuberalis of the pituitary gland, which translates photoperiodic information into neuroendocrine responses. Heterologous expression of Opsin 5 in Xenopus oocytes resulted in light-dependent activation of membrane currents, the action spectrum of which showed peak sensitivity (lambda(max)) at approximately 420 nm. We also found that short-wavelength light, i.e., between UV-B and blue light, induced photoperiodic responses in eye-patched, pinealectomized quail. Thus, Opsin 5 appears to be one of the deepbrain photoreceptive molecules that regulates seasonal reproduction in birds.
Bachman,
Fluorescence of bone.
1965,
Pubmed
Boswell,
Cellular localization of neuropeptide Y mRNA and peptide in the brain of the Japanese quail and domestic chicken.
1998,
Pubmed
Brainard,
Effect of light irradiance and wavelength on the Syrian hamster reproductive system.
1986,
Pubmed
Chaurasia,
Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types.
2005,
Pubmed
,
Xenbase
Foster,
Immunocytochemical markers revealing retinal and pineal but not hypothalamic photoreceptor systems in the Japanese quail.
1987,
Pubmed
Foster,
Rhodopsin-like sensitivity of extra-retinal photoreceptors mediating the photoperiodic response in quail.
,
Pubmed
Halford,
VA opsin-based photoreceptors in the hypothalamus of birds.
2009,
Pubmed
Hanks,
Molecular cloning and sequence analysis of putative chicken prolactin cDNA.
1989,
Pubmed
Hanon,
Ancestral TSH mechanism signals summer in a photoperiodic mammal.
2008,
Pubmed
Hattar,
Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.
2003,
Pubmed
Ikegami,
Localization of circadian clock protein BMAL1 in the photoperiodic signal transduction machinery in Japanese quail.
2009,
Pubmed
Jenkins,
VA opsin, melanopsin, and an inherent light response within retinal interneurons.
2003,
Pubmed
Koyanagi,
Jellyfish vision starts with cAMP signaling mediated by opsin-G(s) cascade.
2008,
Pubmed
Kubo,
Structural basis for a Ca2+-sensing function of the metabotropic glutamate receptors.
1998,
Pubmed
,
Xenbase
Lamb,
Photoreceptor spectral sensitivities: common shape in the long-wavelength region.
1995,
Pubmed
Menaker,
Extraretinal light perception in the sparrow. 3. The eyes do not participate in photoperiodic photoreception.
1970,
Pubmed
Nakao,
Thyrotrophin in the pars tuberalis triggers photoperiodic response.
2008,
Pubmed
Nakao,
Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds.
2006,
Pubmed
Noce,
Molecular cloning and nucleotide sequence analysis of the putative cDNA for the precursor molecule of the chicken LH-beta subunit.
1989,
Pubmed
Oliver,
Brain photoreceptors for the photo-induced testicular response in birds.
1982,
Pubmed
Ono,
Involvement of thyrotropin in photoperiodic signal transduction in mice.
2008,
Pubmed
Panda,
Melanopsin is required for non-image-forming photic responses in blind mice.
2003,
Pubmed
Pierce,
Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.
1993,
Pubmed
Provencio,
Shedding light on photoperiodism.
2010,
Pubmed
Qiu,
Induction of photosensitivity by heterologous expression of melanopsin.
2005,
Pubmed
Sharp,
The effect of hypothalamic lesions on gonadotrophin release in Japanese quail (Coturnix coturnix japonica).
1969,
Pubmed
Shibusawa,
A comparative cytogenetic study of chromosome homology between chicken and Japanese quail.
2001,
Pubmed
Silver,
Coexpression of opsin- and VIP-like-immunoreactivity in CSF-contacting neurons of the avian brain.
1988,
Pubmed
Siopes,
Extraocular modification of photoreception in intact and pinealectomized coturnix.
1974,
Pubmed
Tarttelin,
Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.
2003,
Pubmed
Vigh,
Actual problems of the cerebrospinal fluid-contacting neurons.
1998,
Pubmed
Vigh-Teichmann,
Comparison of the pineal complex, retina and cerebrospinal fluid contacting neurons by immunocytochemical antirhodopsin reaction.
1980,
Pubmed
Wada,
Identification of rhodopsin in the pigeon deep brain.
1998,
Pubmed
Yoshida,
Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.
2001,
Pubmed
Yoshimura,
Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice.
1996,
Pubmed
Yoshimura,
Molecular analysis of avian circadian clock genes.
2000,
Pubmed
Yoshimura,
Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds.
2003,
Pubmed
