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Genes Dev
1997 Nov 01;1121:2883-96. doi: 10.1101/gad.11.21.2883.
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end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.
Zhu J
,
Hill RJ
,
Heid PJ
,
Fukuyama M
,
Sugimoto A
,
Priess JR
,
Rothman JH
.
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The endoderm in the nematode Caenorhabditis elegans is clonally derived from the E founder cell. We identified a single genomic region (the endoderm-determining region, or EDR) that is required for the production of the entire C. elegans endoderm. In embryos lacking the EDR, the E cell gives rise to ectoderm and mesoderm instead of endoderm and appears to adopt the fate of its cousin, the C founder cell. end-1, a gene from the EDR, restores endoderm production in EDR deficiency homozygotes. end-1 transcripts are first detectable specifically in the E cell, consistent with a direct role for end-1 in endoderm development. The END-1 protein is an apparent zinc finger-containing GATA transcription factor. As GATA factors have been implicated in endoderm development in other animals, our findings suggest that endoderm may be specified by molecularly conserved mechanisms in triploblastic animals. We propose that end-1, the first zygotic gene known to be involved in the specification of germ layer and founder cell identity in C. elegans, may link maternal genes that regulate the establishment of the endoderm to downstream genes responsible for endoderm differentiation.
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9353257
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Aamodt,
Spatial control of gut-specific gene expression during Caenorhabditis elegans development.
1991, Pubmed
Aamodt,
Spatial control of gut-specific gene expression during Caenorhabditis elegans development.
1991,
Pubmed
Albertson,
Cell cycling and DNA replication in a mutant blocked in cell division in the nematode Caenorhabditis elegans.
1978,
Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Arceci,
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
1993,
Pubmed
Austin,
Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans.
1989,
Pubmed
Bektesh,
Presence of the Caenorhabditis elegans spliced leader on different mRNAs and in different genera of nematodes.
1988,
Pubmed
Blackwell,
Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.
1994,
Pubmed
Bowerman,
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos.
1993,
Pubmed
Bowerman,
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo.
1992,
Pubmed
Brenner,
The genetics of Caenorhabditis elegans.
1974,
Pubmed
Cowan,
Mapping the distribution of differentiation potential for intestine, muscle, and hypodermis during early development in Caenorhabditis elegans.
1985,
Pubmed
Deppe,
Cell lineages of the embryo of the nematode Caenorhabditis elegans.
1978,
Pubmed
Edgar,
Embryonic expression of a gut-specific esterase in Caenorhabditis elegans.
1986,
Pubmed
Edgar,
Early transcription in Caenorhabditis elegans embryos.
1994,
Pubmed
Edgar,
DNA synthesis and the control of embryonic gene expression in C. elegans.
1988,
Pubmed
Evans,
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.
1988,
Pubmed
Goh,
Positioning and maintenance of embryonic body wall muscle attachments in C. elegans requires the mup-1 gene.
1991,
Pubmed
Goldstein,
An analysis of the response to gut induction in the C. elegans embryo.
1995,
Pubmed
Goldstein,
Induction of gut in Caenorhabditis elegans embryos.
1992,
Pubmed
Goldstein,
Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions.
1993,
Pubmed
Guo,
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
1995,
Pubmed
Hannon,
Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.
1991,
Pubmed
Hird,
Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans.
1993,
Pubmed
Hunter,
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos.
1996,
Pubmed
Kemphues,
Identification of genes required for cytoplasmic localization in early C. elegans embryos.
1988,
Pubmed
Krause,
A trans-spliced leader sequence on actin mRNA in C. elegans.
1987,
Pubmed
Labouesse,
The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates.
1996,
Pubmed
Lambie,
Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.
1991,
Pubmed
Laudet,
Ancestry and diversity of the HMG box superfamily.
1993,
Pubmed
Laufer,
Segregation of developmental potential in early embryos of Caenorhabditis elegans.
1980,
Pubmed
Laverriere,
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
1994,
Pubmed
Lee,
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells.
1991,
Pubmed
Lin,
pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos.
1995,
Pubmed
MacMorris,
Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter.
1992,
Pubmed
Mello,
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.
1991,
Pubmed
Mello,
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.
1992,
Pubmed
Mello,
The PIE-1 protein and germline specification in C. elegans embryos.
1996,
Pubmed
Miller,
Differential localization of two myosins within nematode thick filaments.
1983,
Pubmed
Moskowitz,
Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.
1994,
Pubmed
Nusse,
Wnt genes.
1992,
Pubmed
Okamoto,
Monoclonal antibodies which distinguish certain classes of neuronal and supporting cells in the nervous tissue of the nematode Caenorhabditis elegans.
1985,
Pubmed
Powell-Coffman,
Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA.
1996,
Pubmed
Priess,
Cellular interactions in early C. elegans embryos.
1987,
Pubmed
Priess,
Caenorhabditis elegans morphogenesis: the role of the cytoskeleton in elongation of the embryo.
1986,
Pubmed
Rehorn,
A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.
1996,
Pubmed
Reuter,
The gene serpent has homeotic properties and specifies endoderm versus ectoderm within the Drosophila gut.
1994,
Pubmed
Rocheleau,
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
1997,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schierenberg,
Control of cell-cycle timing in early embryos of Caenorhabditis elegans.
1985,
Pubmed
Schnabel,
Cellular interactions involved in the determination of the early C. elegans embryo.
1991,
Pubmed
Seydoux,
Repression of gene expression in the embryonic germ lineage of C. elegans.
1996,
Pubmed
Seydoux,
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans.
1994,
Pubmed
Stroeher,
DNA-protein interactions in the Caenorhabditis elegans embryo: oocyte and embryonic factors that bind to the promoter of the gut-specific ges-1 gene.
1994,
Pubmed
Sulston,
The embryonic cell lineage of the nematode Caenorhabditis elegans.
1983,
Pubmed
Terns,
A deficiency screen for zygotic loci required for establishment and patterning of the epidermis in Caenorhabditis elegans.
1997,
Pubmed
Thorpe,
Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.
1997,
Pubmed
Travis,
LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].
1991,
Pubmed
Trent,
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
1983,
Pubmed
Tsai,
Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.
1991,
Pubmed
Williams,
A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites.
1992,
Pubmed
Zon,
Expression of GATA-binding proteins during embryonic development in Xenopus laevis.
1991,
Pubmed
,
Xenbase
Zorio,
Operons as a common form of chromosomal organization in C. elegans.
1994,
Pubmed
