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Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes.
Kelso SR
,
Nelson TE
,
Leonard JP
.
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1. N-Methyl-D-aspartate (NMDA) receptors were expressed in Xenopus oocytes injected with rat brain RNA. The modulation of NMDA-induced currents was examined by activating protein kinase C (PKC) either directly (using phorbol esters) or indirectly (via metabotropic glutamate agonists). 2. Bath application of the PKC activator, 4-beta-phorbol-12,13-dibutyrate (PDBu) resulted in a two-fold increase in the NMDA-evoked current at all holding potentials examined (-80 to 0 mV). The inactive (alpha) stereoisomer of phorbol ester was ineffective. 3. The increase was observed under conditions that eliminate the oocyte's endogenous calcium-dependent chloride current, which often contributes to the NMDA response in oocytes. 4. The PDBu effect was specific to the NMDA subclass of glutamate receptors in that no increase was observed in the responses to two other glutamate agonists, kainate and AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid). 5. Stimulation of PKC by activation of metabotropic receptors via either quisqualate or trans-ACPD (trans-1-aminocyclopentane-1,3-dicarboxylic acid) also led to an increase in NMDA currents. 6. Both methods of enhancement induced transient effects. PDBu effects lasted 10-45 min, depending upon both dose and length of application. Quisqualate and trans-ACPD effects were shorter, lasting less than 10 min under these conditions of application. 7. Both methods of enhancement were blocked by the PKC inhibitor, staurosporine. In addition, the phorbol ester-induced enhancement of NMDA responses occluded further enhancement by quisqualate. 8. The results suggest a role for metabotropic glutamate receptors in modulation of NMDA-mediated processes.
Akers,
Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.
1986, Pubmed
Akers,
Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.
1986,
Pubmed
Barish,
A transient calcium-dependent chloride current in the immature Xenopus oocyte.
1983,
Pubmed
,
Xenbase
Bashir,
Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus.
1991,
Pubmed
Bosma,
Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.
1989,
Pubmed
Chen,
Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid.
1991,
Pubmed
Collingridge,
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.
1983,
Pubmed
Davies,
Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation.
1989,
Pubmed
Dierks,
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus.
1981,
Pubmed
Dingledine,
Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice.
1986,
Pubmed
Fong,
Further evidence demonstrating that N-methyl-D-aspartate and kainate activate distinct ion channels.
1989,
Pubmed
,
Xenbase
Gerber,
Multiple effects of phorbol esters in the rat spinal dorsal horn.
1989,
Pubmed
Gundersen,
Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes.
1984,
Pubmed
,
Xenbase
Gustafsson,
Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials.
1987,
Pubmed
Harris,
Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors.
1984,
Pubmed
Hockberger,
A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation.
1989,
Pubmed
Hu,
Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation.
,
Pubmed
Ito,
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
1990,
Pubmed
,
Xenbase
Kauer,
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus.
1988,
Pubmed
Kleckner,
Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes.
1988,
Pubmed
,
Xenbase
Kushner,
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.
1988,
Pubmed
,
Xenbase
Leonard,
Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current.
1990,
Pubmed
,
Xenbase
Lovinger,
Protein kinase C inhibitors eliminate hippocampal long-term potentiation.
1987,
Pubmed
Lovinger,
Direct relation of long-term synaptic potentiation to phosphorylation of membrane protein F1, a substrate for membrane protein kinase C.
1986,
Pubmed
Lynch,
Intracellular injections of EGTA block induction of hippocampal long-term potentiation.
,
Pubmed
MacDonald,
Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture.
1989,
Pubmed
Malenka,
Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.
1988,
Pubmed
Malenka,
Potentiation of synaptic transmission in the hippocampus by phorbol esters.
,
Pubmed
Malinow,
Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.
1989,
Pubmed
Mayer,
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
,
Pubmed
Mayer,
Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
1987,
Pubmed
Miledi,
A calcium-dependent transient outward current in Xenopus laevis oocytes.
1982,
Pubmed
,
Xenbase
Mody,
Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons.
1988,
Pubmed
Morris,
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5.
,
Pubmed
Muller,
Phorbol ester-induced synaptic facilitation is different than long-term potentiation.
1988,
Pubmed
Muller,
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP.
1988,
Pubmed
Nakano,
Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.
1987,
Pubmed
Nicoll,
The current excitement in long-term potentiation.
1988,
Pubmed
Nowak,
Magnesium gates glutamate-activated channels in mouse central neurones.
,
Pubmed
Oosawa,
Rat brain glutamate receptors activate chloride channels in Xenopus oocytes coupled by inositol trisphosphate and Ca2+.
1989,
Pubmed
,
Xenbase
Schrama,
Long-term potentiation and 4-aminopyridine-induced changes in protein and lipid phosphorylation in the hippocampal slice.
1986,
Pubmed
Sigel,
Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels.
1988,
Pubmed
,
Xenbase
Sladeczek,
Glutamate stimulates inositol phosphate formation in striatal neurones.
,
Pubmed
Stratton,
Excitation of hippocampal neurons by stimulation of glutamate Qp receptors.
1989,
Pubmed
Sugiyama,
Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA.
1989,
Pubmed
,
Xenbase
Sugiyama,
A new type of glutamate receptor linked to inositol phospholipid metabolism.
,
Pubmed
,
Xenbase
Tamaoki,
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
1986,
Pubmed
Tsumoto,
NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats.
,
Pubmed
Verdoorn,
Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
1987,
Pubmed
,
Xenbase
Wigström,
Mode of action of excitatory amino acid receptor antagonists on hippocampal long-lasting potentiation.
1986,
Pubmed
