Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1995 Dec 05;9225:11796-800.
Show Gene links
Show Anatomy links
Susceptibility of cloned K+ channels to reactive oxygen species.
Duprat F
,
Guillemare E
,
Romey G
,
Fink M
,
Lesage F
,
Lazdunski M
,
Honore E
.
???displayArticle.abstract???
Free radical-induced oxidant stress has been implicated in a number of physiological and pathophysiological states including ischemia and reperfusion-induced dysrhythmia in the heart, apoptosis of T lymphocytes, phagocytosis, and neurodegeneration. We have studied the effects of oxidant stress on the native K+ channel from T lymphocytes and on K+ channels cloned from cardiac, brain, and T-lymphocyte cells and expressed in Xenopus oocytes. The activity of three Shaker K+ channels (Kv1.3, Kv1.4, and Kv1.5), one Shaw channel (Kv3.4), and one inward rectifier K+ channel (IRK3) was drastically inhibited by photoactivation of rose bengal, a classical generator of reactive oxygen species. Other channel types (such as Shaker K+ channel Kv1.2, Shab channels Kv2.1 and Kv2.2, Shal channel Kv4.1, inward rectifiers IRK1 and ROMK1, and hIsK) were completely resistant to this treatment. On the other handtert-butyl hydroperoxide, another generator of reactive oxygen species, removed the fast inactivation processes of Kv1.4 and Kv3.4 but did not alter other channels. Xanthine/xanthine oxidase system had no effect on all channels studied. Thus, we show that different types of K+ channels are differently modified by reactive oxygen species, an observation that might be of importance in disease states.
Attali,
The protein IsK is a dual activator of K+ and Cl- channels.
1993, Pubmed,
Xenbase
Attali,
The protein IsK is a dual activator of K+ and Cl- channels.
1993,
Pubmed
,
Xenbase
Attali,
Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel.
1993,
Pubmed
,
Xenbase
Attali,
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
1992,
Pubmed
,
Xenbase
Baldwin,
Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel.
1991,
Pubmed
,
Xenbase
Bing,
Hypothesis: apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload.
1994,
Pubmed
Bright,
Apoptosis: programmed cell death in health and disease.
1994,
Pubmed
Di Mascio,
Singlet molecular oxygen production in the reaction of peroxynitrite with hydrogen peroxide.
1994,
Pubmed
Doupnik,
The inward rectifier potassium channel family.
1995,
Pubmed
Frech,
A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
1989,
Pubmed
,
Xenbase
Grinstein,
Ion transport, membrane potential, and cytoplasmic pH in lymphocytes: changes during activation.
1989,
Pubmed
Guillemare,
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.
1992,
Pubmed
,
Xenbase
Hess,
Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.
1984,
Pubmed
Ho,
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
1993,
Pubmed
,
Xenbase
Honoré,
Different types of K+ channel current are generated by different levels of a single mRNA.
1992,
Pubmed
,
Xenbase
Hwang,
A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization.
1992,
Pubmed
Jan,
Structural elements involved in specific K+ channel functions.
1992,
Pubmed
Khan,
Singlet molecular oxygen evolution upon simple acidification of aqueous hypochlorite: application to studies on the deleterious health effects of chlorinated drinking water.
1994,
Pubmed
Kubo,
Primary structure and functional expression of a mouse inward rectifier potassium channel.
1993,
Pubmed
,
Xenbase
Kukreja,
Protective effects of histidine during ischemia-reperfusion in isolated perfused rat hearts.
1993,
Pubmed
Kuo,
Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.
1993,
Pubmed
Kusama,
Singlet oxygen-induced arrhythmias. Dose- and light-response studies for photoactivation of rose bengal in the rat heart.
1989,
Pubmed
Lee,
Laser flash photokinetic studies of rose bengal sensitized photodynamic interactions of nucleotides and DNA.
1987,
Pubmed
Lesage,
Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.
1994,
Pubmed
,
Xenbase
Lingueglia,
Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone.
1994,
Pubmed
,
Xenbase
Matsuura,
Effects of oxidant stress on steady-state background currents in isolated ventricular myocytes.
1991,
Pubmed
Olanow,
A radical hypothesis for neurodegeneration.
1993,
Pubmed
Oxford,
Internal and external application of photodynamic sensitizers on squid giant axons.
1977,
Pubmed
Pongs,
Molecular biology of voltage-dependent potassium channels.
1992,
Pubmed
Ruppersberg,
Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation.
1991,
Pubmed
,
Xenbase
Schröter,
Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain.
1991,
Pubmed
,
Xenbase
Siesjö,
Free radicals and brain damage.
1989,
Pubmed
Steinbeck,
Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap.
1992,
Pubmed
Tarr,
Properties of cardiac I(leak) induced by photosensitizer-generated reactive oxygen.
1994,
Pubmed
Tseng-Crank,
Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library.
1990,
Pubmed
,
Xenbase
Valenzeno,
Membrane photomodification of cardiac myocytes: potassium and leakage currents.
1991,
Pubmed
Vega-Saenz de Miera,
Modulation of K+ channels by hydrogen peroxide.
1992,
Pubmed
,
Xenbase
Wang,
Renal potassium channels and their regulation.
1992,
Pubmed
Yu,
Cellular defenses against damage from reactive oxygen species.
1994,
Pubmed
