Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Owing to the high incidence of multi-drug resistance and challenges posed by the complex and long duration of treatments, Mycobacterium tuberculosis (Mtb) infections remain a significant clinical burden, which would benefit from development of novel immuno-therapeutic-based treatment strategies. Among early immune effectors, invariant or innate-like (i)T cells are attracting attention because of their potential regulatory activity, which can shape anti-mycobacterial immune responses. Unlike conventional T cells, iT cells express a semi-invariant T cell receptor, and respond rapidly and robustly to molecular patterns presented by MHC class I-like molecules. To date, functional studies of iT cells in vivo has been problematic and the role of iT cells in anti-Mtb responses remains unclear. Here, after reviewing the recent literature on anti-mycobacterial iT cell immunity, we describe a novel alternative model system in the amphibian Xenopus laevis tadpoles during infection with Mycobacterium marinum (Mm). X. laevis tadpoles rely mostly on a few distinct prominent innate-like (i)T cell subsets, whose development and function are governed by distinct MHC class I-like molecules. Thus, X. laevis tadpoles provide a convenient and cost-effective in vivo model uniquely suited to investigate the roles of iT cells during mycobacterial infections. We have developed reverse genetics and MHC tetramer technology to characterize this MHC-like/iT system in tadpoles. Our study in X. laevis provides evidence of a conserved convergent function of iT cells in host defenses against mycobacteria between mammals and amphibians.
Andersen,
Novel vaccination strategies against tuberculosis.
2014, Pubmed
Andersen,
Novel vaccination strategies against tuberculosis.
2014,
Pubmed
Behar,
Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.
1999,
Pubmed
Brennan,
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.
2013,
Pubmed
Corbett,
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
2014,
Pubmed
Edholm,
Evolution of innate-like T cells and their selection by MHC class I-like molecules.
2016,
Pubmed
,
Xenbase
Edholm,
Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians.
2013,
Pubmed
,
Xenbase
Edholm,
Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus.
2018,
Pubmed
,
Xenbase
Erman,
Early TCRalpha expression generates TCRalphagamma complexes that signal the DN-to-DP transition and impair development.
2002,
Pubmed
Exley,
Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells.
1997,
Pubmed
Flajnik,
A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus.
1993,
Pubmed
,
Xenbase
Flynn,
Immunology of tuberculosis.
2001,
Pubmed
Gold,
Human mucosal associated invariant T cells detect bacterially infected cells.
2010,
Pubmed
Goldfinch,
Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen.
2010,
Pubmed
Greene,
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
2017,
Pubmed
Huang,
Targeting Innate-Like T Cells in Tuberculosis.
2016,
Pubmed
Huang,
MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution.
2009,
Pubmed
Jiang,
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling.
2016,
Pubmed
Jiang,
Mucosal-associated invariant T-cell function is modulated by programmed death-1 signaling in patients with active tuberculosis.
2014,
Pubmed
Jo,
Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.
2014,
Pubmed
Joyce,
NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors.
2011,
Pubmed
Kawachi,
MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response.
2006,
Pubmed
Kawano,
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.
1997,
Pubmed
Kinjo,
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
2006,
Pubmed
Kwon,
Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity.
2015,
Pubmed
Le Bourhis,
Antimicrobial activity of mucosal-associated invariant T cells.
2010,
Pubmed
Martin,
Stepwise development of MAIT cells in mouse and human.
2009,
Pubmed
Mittrücker,
Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.
2007,
Pubmed
Paredes,
Xenopus: An in vivo model for imaging the inflammatory response following injury and bacterial infection.
2015,
Pubmed
,
Xenbase
Porcelli,
Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.
1993,
Pubmed
Rothchild,
iNKT cell production of GM-CSF controls Mycobacterium tuberculosis.
2014,
Pubmed
Rothchild,
Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection.
2017,
Pubmed
Sada-Ovalle,
Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.
2008,
Pubmed
Salter-Cid,
Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes.
1998,
Pubmed
,
Xenbase
Sköld,
Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation.
2005,
Pubmed
Terrence,
Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells.
2000,
Pubmed
Van Rhijn,
A conserved human T cell population targets mycobacterial antigens presented by CD1b.
2013,
Pubmed
Van Rhijn,
CD1 and mycobacterial lipids activate human T cells.
2015,
Pubmed
Wu,
Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins.
2015,
Pubmed
