XB-ART-682
Curr Opin Cell Biol
2006 Apr 01;182:192-8. doi: 10.1016/j.ceb.2006.01.001.
Show Gene links
Show Anatomy links
CDK activation by non-cyclin proteins.
???displayArticle.abstract???
Progression through the cell cycle is regulated by cyclin-dependent kinases (CDKs), which associate with activating partners, named cyclins, to phosphorylate substrates efficiently. Cyclins are periodically synthesized and degraded during the cell cycle, playing a key role in the precise activation and inactivation of CDKs. However, CDKs can also be activated by other proteins, which lack sequence similarity to cyclins. These include the RINGO/Speedy proteins, which were originally identified as regulators of the meiotic cell cycle in Xenopus oocytes. Recently, five different mammalian RINGO/Speedy family members have been reported, all of which can bind to and directly activate Cdk1 and Cdk2.
???displayArticle.pubmedLink??? 16488127
???displayArticle.link??? Curr Opin Cell Biol
Species referenced: Xenopus
Genes referenced: cdk1 cdk2