Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Euteleost fishes seem to have more copies of many genes than their tetrapod relatives. Three different mechanisms could explain the origin of these 'extra' fish genes. The duplicates may have been produced during a fish-specific genome duplication event. A second explanation is an increased rate of independent gene duplications in fish. A third possibility is that after gene or genome duplication events in the common ancestor of fish and tetrapods, the latter lost more genes. These three hypotheses have been tested by phylogenetic tree reconstruction. Phylogenetic analyses of sequences from human, mouse, chicken, frog (Xenopus laevis), zebrafish (Danio rerio) and pufferfish (Takifugu rubripes) suggest that ray-finned fishes are likely to have undergone a whole genome duplication event between 200 and 450 million years ago. We also comment here on the evolutionary consequences of this ancient genome duplication.
Altschmied,
Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish.
2002, Pubmed
Altschmied,
Subfunctionalization of duplicate mitf genes associated with differential degeneration of alternative exons in fish.
2002,
Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Amores,
Zebrafish hox clusters and vertebrate genome evolution.
1998,
Pubmed
Aparicio,
Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes.
1997,
Pubmed
Chiang,
Characterization of duplicated zebrafish cyp19 genes.
2001,
Pubmed
Davis,
Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum.
1991,
Pubmed
,
Xenbase
Ekker,
Relationships among msx gene structure and function in zebrafish and other vertebrates.
1997,
Pubmed
Force,
Preservation of duplicate genes by complementary, degenerative mutations.
1999,
Pubmed
Gardner,
Expression patterns of engrailed-like proteins in the chick embryo.
1992,
Pubmed
Gates,
A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences.
1999,
Pubmed
Gibson,
Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins.
1998,
Pubmed
Holland,
Hox genes and chordate evolution.
1996,
Pubmed
Holland,
Vertebrate evolution: something fishy about Hox genes.
1997,
Pubmed
Hughes,
The evolution of functionally novel proteins after gene duplication.
1994,
Pubmed
,
Xenbase
Hughes,
Phylogenies of developmentally important proteins do not support the hypothesis of two rounds of genome duplication early in vertebrate history.
1999,
Pubmed
Hughes,
Ancient genome duplications did not structure the human Hox-bearing chromosomes.
2001,
Pubmed
Imboden,
Phylogenetic relationships and chromosomal location of five distinct glycine receptor subunit genes in the teleost Danio rerio.
2001,
Pubmed
Joyner,
En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.
1987,
Pubmed
Laforest,
Involvement of the sonic hedgehog, patched 1 and bmp2 genes in patterning of the zebrafish dermal fin rays.
1998,
Pubmed
Lundin,
Gene duplications in early metazoan evolution.
1999,
Pubmed
Lynch,
The probability of duplicate gene preservation by subfunctionalization.
2000,
Pubmed
Lynch,
The evolutionary fate and consequences of duplicate genes.
2000,
Pubmed
Martínez-Barberá,
Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.
1997,
Pubmed
,
Xenbase
Mellgren,
The evolution of morphological complexity in zebrafish stripes.
2002,
Pubmed
Meyer,
Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions.
1999,
Pubmed
Naruse,
A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution.
2000,
Pubmed
Nowak,
Evolution of genetic redundancy.
1997,
Pubmed
Ohno,
The one-to-four rule and paralogues of sex-determining genes.
1999,
Pubmed
Patel,
Beyond the Hox complex.
2000,
Pubmed
Postlethwait,
Zebrafish comparative genomics and the origins of vertebrate chromosomes.
2000,
Pubmed
Robinson-Rechavi,
Euteleost fish genomes are characterized by expansion of gene families.
2001,
Pubmed
Robinson-Rechavi,
An ancestral whole-genome duplication may not have been responsible for the abundance of duplicated fish genes.
2001,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Schulte,
Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration.
1997,
Pubmed
Sidow,
Gen(om)e duplications in the evolution of early vertebrates.
1996,
Pubmed
Spring,
Vertebrate evolution by interspecific hybridisation--are we polyploid?
1997,
Pubmed
Taylor,
Comparative genomics provides evidence for an ancient genome duplication event in fish.
2001,
Pubmed
,
Xenbase
Taylor,
2R or not 2R?
2001,
Pubmed
Taylor,
Genome duplication, divergent resolution and speciation.
2001,
Pubmed
Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed
Van de Peer,
Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes.
2002,
Pubmed
Van de Peer,
TREECON for Windows: a software package for the construction and drawing of evolutionary trees for the Microsoft Windows environment.
1994,
Pubmed
Van de Peer,
The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes.
2001,
Pubmed
,
Xenbase
Van de Peer,
Wanda: a database of duplicated fish genes.
2002,
Pubmed
,
Xenbase
Wang,
Evolutionary patterns of gene families generated in the early stage of vertebrates.
2000,
Pubmed
Woods,
A comparative map of the zebrafish genome.
2000,
Pubmed
