Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Genome Res
2000 Oct 01;1010:1453-62. doi: 10.1101/gr.144100.
Show Gene links
Show Anatomy links
Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development.
Peters T
,
Dildrop R
,
Ausmeier K
,
Rüther U
.
???displayArticle.abstract???
Iroquois proteins comprise a conserved family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. Earlier studies identified four murine Iroquois (Irx) genes. Here we report the isolation of two additional members of the murine gene family, Irx5 and Irx6. Phylogenetic analysis of the Irx gene family revealed distinct clades for fly and vertebrate genes, and vertebrate members themselves were classified into three pairs of cognate genes. Mapping of the murine Irx genes identified two gene clusters located on mouse chromosomes 8 and 13, respectively. Each gene cluster is represented by three Irx genes whose relative positions within both clusters are strictly conserved. Combined results from phylogenetic, linkage, and physical mapping studies provide evidence for the evolution of two Irx gene clusters by duplication of a larger chromosomal region and dispersion to two chromosomal locations. The maintenance of two cognate Irx gene clusters during vertebrate evolution suggests that their genomic organization is important for the regulation, expression, and function of Irx genes during embryonic development.
Agulnik,
Evolution of mouse T-box genes by tandem duplication and cluster dispersion.
1996, Pubmed
Agulnik,
Evolution of mouse T-box genes by tandem duplication and cluster dispersion.
1996,
Pubmed
Alonso,
The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.
1988,
Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Aparicio,
Vertebrate evolution: recent perspectives from fish.
2000,
Pubmed
Bao,
Regulation of chamber-specific gene expression in the developing heart by Irx4.
1999,
Pubmed
Bellefroid,
Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification.
1998,
Pubmed
,
Xenbase
Bosse,
Identification of a novel mouse Iroquois homeobox gene, Irx5, and chromosomal localisation of all members of the mouse Iroquois gene family.
2000,
Pubmed
Bosse,
Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.
1997,
Pubmed
Bruneau,
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.
2000,
Pubmed
,
Xenbase
Bürglin,
Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.
1997,
Pubmed
Cavodeassi,
Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins.
1999,
Pubmed
Cohen,
Expression of two novel mouse Iroquois homeobox genes during neurogenesis.
2000,
Pubmed
,
Xenbase
Copeland,
Genome maps IV 1993. Wall chart.
1993,
Pubmed
Dib,
A comprehensive genetic map of the human genome based on 5,264 microsatellites.
1996,
Pubmed
Dietrich,
A genetic map of the mouse with 4,006 simple sequence length polymorphisms.
1994,
Pubmed
Dietrich,
A comprehensive genetic map of the mouse genome.
1996,
Pubmed
Diez del Corral,
The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.
1999,
Pubmed
Duboule,
Vertebrate hox gene regulation: clustering and/or colinearity?
1998,
Pubmed
Finnerty,
The evolution of the Hox cluster: insights from outgroups.
1998,
Pubmed
Funayama,
Coelom formation: binary decision of the lateral plate mesoderm is controlled by the ectoderm.
1999,
Pubmed
Gomez-Skarmeta,
Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes.
1996,
Pubmed
Gómez-Skarmeta,
Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate.
1998,
Pubmed
,
Xenbase
Goriely,
c-Irx2 expression reveals an early subdivision of the neural plate in the chick embryo.
1999,
Pubmed
Grillenzoni,
The iroquois complex controls the somatotopy of Drosophila notum mechanosensory projections.
1998,
Pubmed
Haldi,
A comprehensive large-insert yeast artificial chromosome library for physical mapping of the mouse genome.
1996,
Pubmed
Holland,
Hox genes and chordate evolution.
1996,
Pubmed
Kehl,
mirror, a Drosophila homeobox gene in the Iroquois complex, is required for sensory organ and alula formation.
1998,
Pubmed
Kimura,
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.
1980,
Pubmed
Knust,
Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.
1992,
Pubmed
Kondo,
Breaking colinearity in the mouse HoxD complex.
1999,
Pubmed
Krumlauf,
Hox genes in vertebrate development.
1994,
Pubmed
Lennon,
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.
1996,
Pubmed
Lewis,
Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.
1999,
Pubmed
Leyns,
iroquois: a prepattern gene that controls the formation of bristles on the thorax of Drosophila.
1996,
Pubmed
Mann,
Why are Hox genes clustered?
1997,
Pubmed
McNeill,
mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.
1997,
Pubmed
Netter,
white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster.
1998,
Pubmed
Nusbaum,
A YAC-based physical map of the mouse genome.
1999,
Pubmed
Ruddle,
Gene loss and gain in the evolution of the vertebrates.
1994,
Pubmed
Ruvinsky,
Newly identified paralogous groups on mouse chromosomes 5 and 11 reveal the age of a T-box cluster duplication.
1997,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Skrabanek,
Eukaryote genome duplication - where's the evidence?
1998,
Pubmed
,
Xenbase
Stock,
The evolution of the vertebrate Dlx gene family.
1996,
Pubmed
Tan,
Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system.
1999,
Pubmed
,
Xenbase
