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XB-ART-6211
Nat Neurosci 2002 Dec 01;512:1302-8. doi: 10.1038/nn975.
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A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein.

Wong ST , Henley JR , Kanning KC , Huang KH , Bothwell M , Poo MM .


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Myelin-associated glycoprotein (MAG), an inhibitor of axon regeneration, binds with high affinity to the Nogo-66 receptor (NgR). Here we report that the p75 neurotrophin receptor (p75(NTR)) is a co-receptor of NgR for MAG signaling. In cultured human embryonic kidney (HEK) cells expressing NgR, p75(NTR) was required for MAG-induced intracellular Ca2+ elevation. Co-immunoprecipitation showed an association of NgR with p75(NTR) that can be disrupted by an antibody against p75(NTR) (NGFR5), and extensive coexpression was observed in the developing rat nervous system. Furthermore, NGFR5 abolished MAG-induced repulsive turning of Xenopus axonal growth cones and Ca2+ elevation, both in neurons and in NgR/p75(NTR)-expressing HEK cells. Thus we conclude that p75(NTR) is a co-receptor of NgR for MAG signaling and a potential therapeutic target for promoting nerve regeneration.

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Species referenced: Xenopus
Genes referenced: mag ntsr1 rtn4