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XB-ART-9010
Drug Chem Toxicol 2001 May 01;242:117-27. doi: 10.1081/dct-100102605.
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Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.

Fort DJ , Rogers RL , Paul RR , Stover EL , Finch RA .


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The developmental toxicities of five test compounds including carbon tetrachloride, urethane, phenacetin, parathion, and chloroform, were evaluated using Frog Embryo Teratogenesis Assay--Xenopus (FETAX), with minor modification. Post-isolation mixtures of differently-induced rat liver microsomes (phenobarbital- (PB), beta-naphthoflavone- (beta-NF), and isoniazid- (INH)-induced preparations) were co-cultured directly with X. laevis embryos. Results from these studies suggest that the Aroclor 1254-induced MAS could effectively be replaced by a mixed lot of PB-, beta-NF-, and INH-induced rat liver microsomes. Each of the test materials were found to be developmentally toxic when bioactivated by the mixed MAS.

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