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XB-ART-11777
Curr Opin Cell Biol 1999 Dec 01;116:708-16. doi: 10.1016/s0955-0674(99)00041-1.
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Progression into and out of mitosis.

Zachariae W .


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Progression through mitosis is controlled by cyclin-dependent kinases, which drive cells into metaphase, and by the anaphase-promoting complex/cyclosome, a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis. Recent work has shown how the mutual regulation between cyclin-dependent kinases and the anaphase-promoting complex/cyclosome ensures that cell-cycle events occur in the right order. The analysis of complexes required for sister chromatid cohesion and chromosome condensation has revealed how cyclin-dependent kinases and the anaphase-promoting complex/cyclosome control the behaviour of chromosomes.

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References :
Deshaies, Cell multiplication. Peering in and peering out: regulation of and by the cell cycle. 2000, Pubmed