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Proc Natl Acad Sci U S A
2003 Jan 21;1002:506-10. doi: 10.1073/pnas.0236032100.
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Optimal ion channel clustering for intracellular calcium signaling.
Shuai JW
,
Jung P
.
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Ion channels and receptors in the cell membranes and internal membranes are often distributed in discrete clusters. One particularly well-studied example is the distribution of inositol 1,4,5-triphosphate receptors in the plasma membrane that controls the flux of Ca2+ from the endoplasmic reticulum into the cytosol. By using mathematical modeling, we show that channel clustering can enhance the cell's Ca2+ signaling capability. Furthermore, we predict optimal signaling cellular capability at cluster sizes and distances that agree with experimentally found values in Xenopus oocyte.
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