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XB-ART-26959
Biochem Biophys Res Commun 1989 Jan 31;1582:520-6.
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Polyamine levels during Xenopus laevis oogenesis: a role in oocyte competence to meiotic resumption.

Osborne HB , Mulner-Lorillon O , Marot J , Belle R .


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The results presented here show that a decrease in the concentration of total polyamines, due to a decrease in putrescine and spermine, occurs during oogenesis in Xenopus laevis. The microinjection of spermine or spermidine decreases the hormonal responsiveness (maturation) of the fully-grown oocytes. This effect is synergistic with that already described for the microinjection of casein kinase II (Mulner-Lorillon, O. et al. (1987) Eur. J. Biochem. 171, 107-117), a polyamine dependent enzyme. Therefore a decrease in polyamine concentration, via its effect on endogeneous casein kinase II, could constitute one of the molecular changes required for the acquisition of competence to mature.

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Species referenced: Xenopus laevis
Genes referenced: tbx2