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The use of the Xenopus model system has provided diverse contributions to cancer research, not least because of the striking parallels between tumour pathogenesis and early embryo development. Cell cycle regulation, signalling pathways, and cell behaviours such as migration are frequently perturbed in cancers; all have been investigated using Xenopus, and these developmental events can additionally act as an assay for drug development studies. In this mini-review, we focus our discussion primarily on whole embryo Xenopus models informing cancer biology; the contributions to date and future potential. Insights into tumour immunity, oncogene function, and visualisation of vascular responses during tumour formation have all been achieved with naturally occurring tumours and induced-tumour-like-structures in Xenopus. Finally, as we are now entering the era of genetically modified Xenopus models, we can harness genome editing techniques to recapitulate human disease through creating embryos with analogous genetic abnormalities. With the speed, versatility and accessibility that epitomise the Xenopus system, this new range of pre-clinical Xenopus models has great potential to advance our mechanistic understanding of oncogenesis and provide an early in vivo model for chemotherapeutic development.
FIGURE 1. Using the full Xenopus repertoire to inform on the hallmarks of cancer. Ten hallmarks of cancer are recognised (left) and Xenopus studies have informed on each of these aspects (right) as described in the main text. Where possible review papers are referenced to direct readers to further discussion of each topic. ITLSs, induced-tumour-like-structures; GEXM, genetically engineered Xenopus models.
Aiello,
Echoes of the embryo: using the developmental biology toolkit to study cancer.
2016, Pubmed
Aiello,
Echoes of the embryo: using the developmental biology toolkit to study cancer.
2016,
Pubmed
Asfari,
Mycobacterium-induced infectious granuloma in Xenopus: histopathology and transmissibility.
1988,
Pubmed
,
Xenbase
Asfari,
Transplantation studies of a putative lymphosarcoma of Xenopus.
1988,
Pubmed
,
Xenbase
Banach,
Tumor immunology viewed from alternative animal models-the Xenopus story.
2017,
Pubmed
,
Xenbase
Blackiston,
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway.
2011,
Pubmed
,
Xenbase
Blow,
Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes.
2016,
Pubmed
,
Xenbase
Bui,
Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?
2007,
Pubmed
Chernet,
Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range.
2014,
Pubmed
,
Xenbase
Chernet,
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model.
2013,
Pubmed
,
Xenbase
Cupello,
Cell-free Xenopus egg extracts for studying DNA damage response pathways.
2016,
Pubmed
,
Xenbase
Dahmane,
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.
1997,
Pubmed
,
Xenbase
Deming,
Study of apoptosis in vitro using the Xenopus egg extract reconstitution system.
2006,
Pubmed
,
Xenbase
De Robertis,
Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.
2013,
Pubmed
,
Xenbase
Goyos,
Tumorigenesis and anti-tumor immune responses in Xenopus.
2009,
Pubmed
,
Xenbase
Hanahan,
Hallmarks of cancer: the next generation.
2011,
Pubmed
Hanahan,
The hallmarks of cancer.
2000,
Pubmed
Hardwick,
An oncologist׳s friend: How Xenopus contributes to cancer research.
2015,
Pubmed
,
Xenbase
Hardwick,
Cell cycle regulation of proliferation versus differentiation in the central nervous system.
2015,
Pubmed
Haynes-Gilmore,
A critical role of non-classical MHC in tumor immune evasion in the amphibian Xenopus model.
2014,
Pubmed
,
Xenbase
Haynes-Gimore,
Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.
2015,
Pubmed
,
Xenbase
Hill,
TGF-beta signalling pathways in early Xenopus development.
2001,
Pubmed
,
Xenbase
Hoogenboom,
Xenopus egg extract: A powerful tool to study genome maintenance mechanisms.
2017,
Pubmed
,
Xenbase
Ishizuya-Oka,
Amphibian organ remodeling during metamorphosis: insight into thyroid hormone-induced apoptosis.
2011,
Pubmed
,
Xenbase
Ito,
Apoptotic and survival signaling mediated through death receptor members during metamorphosis in the African clawed frog Xenopus laevis.
2012,
Pubmed
,
Xenbase
Kälin,
An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis.
2009,
Pubmed
,
Xenbase
Klingemann,
Immunotherapy for Dogs: Running Behind Humans.
2018,
Pubmed
Krishnamurthy,
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.
2018,
Pubmed
Kühl,
Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation.
2002,
Pubmed
,
Xenbase
Kühl,
Dorsal axis duplication as a functional readout for Wnt activity.
2008,
Pubmed
,
Xenbase
Levin,
Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form.
2017,
Pubmed
Li,
A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell.
2016,
Pubmed
,
Xenbase
Lobikin,
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo.
2012,
Pubmed
,
Xenbase
Ma,
The relationship between early embryo development and tumourigenesis.
2010,
Pubmed
Naert,
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis.
2016,
Pubmed
,
Xenbase
Naert,
TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models.
2017,
Pubmed
,
Xenbase
Ny,
A transgenic Xenopus laevis reporter model to study lymphangiogenesis.
2013,
Pubmed
,
Xenbase
Ny,
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
2005,
Pubmed
,
Xenbase
Pegoraro,
Signaling and transcriptional regulation in neural crest specification and migration: lessons from xenopus embryos.
2013,
Pubmed
,
Xenbase
Pera,
Active signals, gradient formation and regional specificity in neural induction.
2014,
Pubmed
,
Xenbase
Philpott,
The Xenopus cell cycle: an overview.
2008,
Pubmed
,
Xenbase
Robert,
Lymphoid tumors of Xenopus laevis with different capacities for growth in larvae and adults.
1994,
Pubmed
,
Xenbase
Robert,
Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates.
2010,
Pubmed
Robert,
Evolution of immune surveillance and tumor immunity: studies in Xenopus.
1998,
Pubmed
,
Xenbase
Robert,
Effects of thymectomy and tolerance induction on tumor immunity in adult Xenopus laevis.
1997,
Pubmed
,
Xenbase
Ruben,
Cancer resistance in amphibians.
2007,
Pubmed
,
Xenbase
Schmitt,
Engineering Xenopus embryos for phenotypic drug discovery screening.
2014,
Pubmed
,
Xenbase
Silver,
The Bioelectric Code: Reprogramming Cancer and Aging From the Interface of Mechanical and Chemical Microenvironments.
2018,
Pubmed
Smith,
Understanding how morphogens work.
2008,
Pubmed
,
Xenbase
Tanaka,
Identification of anti-cancer chemical compounds using Xenopus embryos.
2016,
Pubmed
,
Xenbase
Torre,
Global Cancer Incidence and Mortality Rates and Trends--An Update.
2016,
Pubmed
Ureta,
Frog oocytes: a living test tube for studies on metabolic regulation.
2001,
Pubmed
,
Xenbase
Van Nieuwenhuysen,
TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis.
2015,
Pubmed
,
Xenbase
Waaler,
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
2011,
Pubmed
,
Xenbase
Wallingford,
p53 activity is essential for normal development in Xenopus.
1997,
Pubmed
,
Xenbase
Wallingford,
Tumors in tadpoles: the Xenopus embryo as a model system for the study of tumorigenesis.
1999,
Pubmed
,
Xenbase
Whitman,
Involvement of p21ras in Xenopus mesoderm induction.
1992,
Pubmed
,
Xenbase
Whitman,
Induction of mesoderm by a viral oncogene in early Xenopus embryos.
1989,
Pubmed
,
Xenbase
Wylie,
Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma.
2015,
Pubmed
,
Xenbase
Yang,
Overexpression of a novel Xenopus rel mRNA gene induces tumors in early embryos.
1998,
Pubmed
,
Xenbase
Zhang,
Current status and future directions of cancer immunotherapy.
2018,
Pubmed
