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XB-ART-28612
Proc Natl Acad Sci U S A 1986 Jul 01;8314:5150-4.
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Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation.

Guinta DR , Tso JY , Narayanswami S , Hamkalo BA , Korn LJ .


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In Xenopus somatic cells, the somatic-type 5S RNA genes replicate early in S phase, bind the transcription factor TFIIIA, and are expressed; in contrast, the late replicating oocyte-type genes do not bind TFIIIA and are transcriptionally inactive. These facts support a model in which the order of replication of the somatic-type versus the oocyte-type 5S genes causes their differential expression in somatic cells due to sequestration of TFIIIA by the early-replicating somatic genes. Here we provide further evidence for the model by showing that in one Xenopus cell line in which some oocyte-type 5S genes are translocated, some oocyte-type 5S genes replicate early and are expressed.

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Species referenced: Xenopus laevis
Genes referenced: gtf3a

References [+] :
Balazs, The temporal order of replication of some DNA cistrons. 1974, Pubmed