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XB-ART-19000
J Biol Chem 1995 Nov 24;27047:28297-303.
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Sequence-specific RNA recognition by the Xenopus Y-box proteins. An essential role for the cold shock domain.

Bouvet P , Matsumoto K , Wolffe AP .


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The Xenopus Y-box protein FRGY2 has a role in the translational silencing of masked maternal mRNA. Here, we determine that FRGY2 will recognize specific RNA sequences. The evolutionarily conserved nucleic acid-binding cold shock domain is required for sequence-specific interactions with RNA. However, RNA binding by FRGY2 is facilitated by N- and C-terminal regions flanking the cold shock domain. The hydrophilic C-terminal tail domain of FRGY2 interacts with RNA independent of the cold shock domain but does not determine sequence specificity. Thus, both sequence-specific and nonspecific RNA recognition domains are contained within the FRGY2 protein.

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Species referenced: Xenopus laevis
Genes referenced: ybx2