de la Peña P , Alonso-Ron C , Machín A , Fernández-Trillo J , Carretero L , Domínguez P , Barros F .

P41 RR001081 NCRR NIH HHS

Alonso-Ron, Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions. 2008, Pubmed, Xenbase

Alonso-Ron, Thermodynamic and kinetic properties of amino-terminal and S4-S5 loop HERG channel mutants under steady-state conditions. 2008, Pubmed , Xenbase
Alonso-Ron, Participation of HERG channel cytoplasmic structures on regulation by the G protein-coupled TRH receptor. 2009, Pubmed , Xenbase
Al-Owais, Role of intracellular domains in the function of the herg potassium channel. 2009, Pubmed
Barghaan, Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels. 2009, Pubmed , Xenbase
Bass, Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis. 2007, Pubmed
Bell, Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination. 2009, Pubmed , Xenbase
Brown, A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating. 2008, Pubmed , Xenbase
Chen, Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. 1999, Pubmed , Xenbase
Chiang, The long QT syndromes: genetic basis and clinical implications. 2000, Pubmed
Choveau, KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. 2011, Pubmed
Falke, Structure of a bacterial sensory receptor. A site-directed sulfhydryl study. 1988, Pubmed
Ferrer, The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel. 2006, Pubmed , Xenbase
Finlayson, Acquired QT interval prolongation and HERG: implications for drug discovery and development. 2004, Pubmed
Gómez-Varela, Influence of amino-terminal structures on kinetic transitions between several closed and open states in human erg K+ channels. 2002, Pubmed , Xenbase
Gómez-Varela, Relevance of the proximal domain in the amino-terminus of HERG channels for regulation by a phospholipase C-coupled hormone receptor. 2003, Pubmed , Xenbase
Gustina, A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. 2009, Pubmed , Xenbase
Horenstein, Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. 2001, Pubmed , Xenbase
Ju, The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel. 2009, Pubmed
Keating, Molecular and cellular mechanisms of cardiac arrhythmias. 2001, Pubmed
Kolbe, Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. 2010, Pubmed
Li, NMR solution structure of the N-terminal domain of hERG and its interaction with the S4-S5 linker. 2010, Pubmed
Liu, Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes. 2003, Pubmed , Xenbase
Liu, Structural and functional role of the extracellular s5-p linker in the HERG potassium channel. 2002, Pubmed , Xenbase
Lu, Effects of premature stimulation on HERG K(+) channels. 2001, Pubmed
Miranda, FRET with multiply labeled HERG K(+) channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains. 2008, Pubmed
Morais Cabral, Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. 1998, Pubmed , Xenbase
Muskett, Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain. 2011, Pubmed
Ng, The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation. 2011, Pubmed
Piper, Gating currents associated with intramembrane charge displacement in HERG potassium channels. 2003, Pubmed , Xenbase
Redfern, Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. 2003, Pubmed
Roden, Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. 1996, Pubmed
Saenen, Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. 2006, Pubmed
Sanguinetti, Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. 1999, Pubmed , Xenbase
Sanguinetti, A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. 1995, Pubmed , Xenbase
Schönherr, Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. 1996, Pubmed , Xenbase
Schwartz, Management of long QT syndrome. 2005, Pubmed
Smith, Fast and slow voltage sensor movements in HERG potassium channels. 2002, Pubmed , Xenbase
Smith, The inward rectification mechanism of the HERG cardiac potassium channel. 1996, Pubmed
Spector, Fast inactivation causes rectification of the IKr channel. 1996, Pubmed , Xenbase
Subbiah, Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel. 2004, Pubmed , Xenbase
Subbiah, Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed. 2005, Pubmed , Xenbase
Thomas, Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein. 2003, Pubmed , Xenbase
Trudeau, HERG, a human inward rectifier in the voltage-gated potassium channel family. 1995, Pubmed
Van Slyke, Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels. 2010, Pubmed , Xenbase
Viloria, Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating. 2000, Pubmed , Xenbase
Viskin, Long QT syndromes and torsade de pointes. 1999, Pubmed
Wang, Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels. 2000, Pubmed , Xenbase
Wang, Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels. 1998, Pubmed , Xenbase
Zhang, Gating charges in the activation and inactivation processes of the HERG channel. 2004, Pubmed , Xenbase
Zhang, Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel. 2005, Pubmed , Xenbase