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XB-ART-41416
Dev Cell 2010 Mar 16;183:338-40. doi: 10.1016/j.devcel.2010.03.001.
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BCL6 and BCoR gang up on Notch to regulate left-right patterning.

Koch U , Radtke F .


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In this issue of Developmental Cell, Sakano et al. describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning.

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Species referenced: Xenopus
Genes referenced: bcl6 bcor notch1 tbx2

References :
Sakano, BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning. 2010, Pubmed, Xenbase