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XB-ART-38145
Proc Natl Acad Sci U S A 2008 Aug 05;10531:10973-7. doi: 10.1073/pnas.0804386105.
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Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes.

Limon A , Reyes-Ruiz JM , Miledi R .


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Autism is a complex disorder that arises from the pervasive action of genetic and epigenetic factors that alter synaptic connectivity of the brain. Although GABA and glutamate receptors seem to be two of those factors, very little is known about the functional properties of the autistic receptors. Autistic tissue samples stored in brain banks usually have relatively long postmortem times, and it is highly desirable to know whether neurotransmitter receptors in such tissues are still functional. Here we demonstrate that native receptors microtransplanted from autistic brains, as well as de novo mRNA-expressed receptors, are still functional and susceptible to detailed electrophysiological characterization even after long postmortem intervals. The opportunity to study the properties of human receptors present in diseased brains not only opens new avenues toward understanding autism and other neurological disorders, but it also makes the microtransplantation method a useful translational system to evaluate and develop novel medicinal drugs.

???displayArticle.pubmedLink??? 18645182
???displayArticle.pmcLink??? PMC2504813
???displayArticle.link??? Proc Natl Acad Sci U S A


GO keywords: glutamate receptor activity [+]

???displayArticle.disOnts??? autism spectrum disorder
???displayArticle.omims??? AUTISM
References [+] :
Atz, Methodological considerations for gene expression profiling of human brain. 2007, Pubmed