XB-ART-51084
Curr Pathobiol Rep
2015 Jun 01;32:137-145. doi: 10.1007/s40139-015-0076-0.
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Xenopus as a Model for GI/Pancreas Disease.
Salanga MC
,
Horb ME
.
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Diseases affecting endodermal organs like the pancreas, lung and gastrointestinal (GI) tract have a substantial impact on human welfare. Since many of these are congenital defects that arise as a result of defects during development broad efforts are focused on understanding the development of these organs so as to better identify risk factors, disease mechanisms and therapeutic targets. Studies implementing model systems, like the amphibian Xenopus, have contributed immensely to our understanding of signaling (e.g. Wnt, FGF, BMP, RA) pathways and gene regulation (e.g. hhex, ptf1a, ngn3) that underlie normal development as well as disease progression. Recent advances in genome engineering further enhance the capabilities of the Xenopus model system for pursuing biomedical research, and will undoubtedly result in a boom of new information underlying disease mechanisms ultimately leading to advancements in diagnosis and therapy.
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Species referenced: Xenopus
Genes referenced: hhex ptf1a
???displayArticle.disOnts??? diabetes mellitus
References [+] :
Afelik,
Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue.
2006, Pubmed,
Xenbase
Afelik, Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. 2006, Pubmed , Xenbase
Bennett, Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia. 2010, Pubmed
Bilogan, Xenopus staufen2 is required for anterior endodermal organ formation. 2012, Pubmed , Xenbase
Bilogan, Microarray analysis of Xenopus endoderm expressing Ptf1a. 2012, Pubmed , Xenbase
Blitz, Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system. 2013, Pubmed , Xenbase
Blitz, Germ layers to organs: using Xenopus to study "later" development. 2006, Pubmed , Xenbase
Cano, Pancreatic development and disease. 2007, Pubmed
Chalmers, The Xenopus tadpole gut: fate maps and morphogenetic movements. 2000, Pubmed , Xenbase
Chung, Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. 2010, Pubmed , Xenbase
Concepcion, Neonatal diabetes, gallbladder agenesis, duodenal atresia, and intestinal malrotation caused by a novel homozygous mutation in RFX6. 2014, Pubmed
Dush, Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut. 2013, Pubmed , Xenbase
Flanagan, Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood. 2007, Pubmed
Guo, Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. 2014, Pubmed , Xenbase
Harrison, A CRISPR view of development. 2014, Pubmed
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Hellsten, Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis. 2007, Pubmed , Xenbase
Horb, BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. 2010, Pubmed , Xenbase
Horb, Experimental conversion of liver to pancreas. 2003, Pubmed , Xenbase
Horb, Endoderm specification and differentiation in Xenopus embryos. 2001, Pubmed , Xenbase
Horb, Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development. 2009, Pubmed , Xenbase
Hsu, Development and applications of CRISPR-Cas9 for genome engineering. 2014, Pubmed
Ishibashi, A method for generating transgenic frog embryos. 2008, Pubmed , Xenbase
James-Zorn, Xenbase: expansion and updates of the Xenopus model organism database. 2013, Pubmed , Xenbase
Jarikji, The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. 2009, Pubmed , Xenbase
Jarikji, Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. 2007, Pubmed , Xenbase
Jørgensen, An illustrated review of early pancreas development in the mouse. 2007, Pubmed
Karpinka, Xenbase, the Xenopus model organism database; new virtualized system, data types and genomes. 2015, Pubmed , Xenbase
Kenny, Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. 2012, Pubmed , Xenbase
Kim, A guide to genome engineering with programmable nucleases. 2014, Pubmed
Kwon, Identifying direct targets of transcription factor Rfx2 that coordinate ciliogenesis and cell movement. 2014, Pubmed , Xenbase
Lei, Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). 2012, Pubmed , Xenbase
Li, Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. 2008, Pubmed , Xenbase
Männikkö, A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated. 2011, Pubmed , Xenbase
Martin, Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels. 2013, Pubmed
McLin, Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. 2007, Pubmed , Xenbase
Mitchell, Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome. 2004, Pubmed
Moody, Fates of the blastomeres of the 32-cell-stage Xenopus embryo. 1987, Pubmed , Xenbase
Musa-Aziz, Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes. 2010, Pubmed , Xenbase
Nakade, Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9. 2014, Pubmed , Xenbase
Nakayama, Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. 2013, Pubmed , Xenbase
Newport, A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. 1982, Pubmed , Xenbase
Newport, A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. 1982, Pubmed , Xenbase
Oropeza, Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells. 2012, Pubmed , Xenbase
Park, Xenopus cDNA microarray identification of genes with endodermal organ expression. 2007, Pubmed , Xenbase
Pearl, Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center. 2012, Pubmed , Xenbase
Pearl, Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes. 2011, Pubmed , Xenbase
Pearl, Xenopus pancreas development. 2009, Pubmed , Xenbase
Peng, Making designer mutants in model organisms. 2014, Pubmed
Polak, Early pattern of differentiation in the human pancreas. 2000, Pubmed
Proks, Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study. 2014, Pubmed , Xenbase
Proks, Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes. 2013, Pubmed , Xenbase
Rankin, Gene regulatory networks governing lung specification. 2014, Pubmed , Xenbase
Rankin, Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. 2012, Pubmed , Xenbase
Rankin, A Molecular atlas of Xenopus respiratory system development. 2015, Pubmed , Xenbase
Rankin, A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. 2011, Pubmed , Xenbase
Rodríguez-Seguel, Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence. 2013, Pubmed , Xenbase
Rose, Plasticity of lung development in the amphibian, Xenopus laevis. 2013, Pubmed , Xenbase
Schmitt, Engineering Xenopus embryos for phenotypic drug discovery screening. 2014, Pubmed , Xenbase
Segerdell, Enhanced XAO: the ontology of Xenopus anatomy and development underpins more accurate annotation of gene expression and queries on Xenbase. 2013, Pubmed , Xenbase
Shifley, Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. 2012, Pubmed , Xenbase
Smith, Rfx6 directs islet formation and insulin production in mice and humans. 2010, Pubmed
Sobczak, Endogenous transport systems in the Xenopus laevis oocyte plasma membrane. 2010, Pubmed , Xenbase
Sun, Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development. 2014, Pubmed , Xenbase
Thulé, Sulfonylureas: a new look at old therapy. 2014, Pubmed
Uno, Homoeologous chromosomes of Xenopus laevis are highly conserved after whole-genome duplication. 2013, Pubmed , Xenbase
Wang, Retinoic acid is a key regulatory switch determining the difference between lung and thyroid fates in Xenopus laevis. 2011, Pubmed , Xenbase
Wheeler, Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. 2009, Pubmed , Xenbase
Wühr, Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database. 2014, Pubmed , Xenbase
Yanai, Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. 2011, Pubmed , Xenbase
Zhang, Retinoic acid-activated Ndrg1a represses Wnt/β-catenin signaling to allow Xenopus pancreas, oesophagus, stomach, and duodenum specification. 2013, Pubmed , Xenbase
Zhang, Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells. 2013, Pubmed , Xenbase
Zhao, Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. 2012, Pubmed , Xenbase
Zorn, Vertebrate endoderm development and organ formation. 2009, Pubmed , Xenbase