XB-ART-51813
Semin Cell Dev Biol
2016 Mar 01;51:117-24. doi: 10.1016/j.semcdb.2016.02.002.
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Using Xenopus to study genetic kidney diseases.
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Modern sequencing technology is revolutionizing our knowledge of inherited kidney disease. However, the molecular role of genes affected by the rapidly rising number of identified mutations is lagging behind. Xenopus is a highly useful, but underutilized model organism with unique properties excellently suited to decipher the molecular mechanisms of kidney development and disease. The embryonic kidney (pronephros) can be manipulated on only one side of the animal and its formation observed directly through the translucent skin. The moderate evolutionary distance between Xenopus and humans is a huge advantage for studying basic principles of kidney development, but still allows us to analyze the function of disease related genes. Optogenetic manipulations and genome editing by CRISPR/Cas are exciting additions to the toolbox for disease modelling and will facilitate the use of Xenopus in translational research. Therefore, the future of Xenopus in kidney research is bright.
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Species referenced: Xenopus
Genes referenced: ace agt anks6 bmp4 eya1 foxc1 hnf1b invs lmx1b nek8 nphp3 pax2 pkd2 six1 six2 sox17a tsc1 wdpcp wnt4 wt1
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