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Xenbase is the Xenopus model organism database ( www.xenbase.org ), a web-accessible resource that integrates the diverse genomic and biological data for Xenopus research. It hosts a variety of content including current and archived genomes for both X. laevis and X. tropicalis, bioinformatic tools for comparative genetic analyses including BLAST and GBrowse, annotated Xenopus literature, and catalogs of reagents including antibodies, ORFeome clones, morpholinos, and transgenic lines. Xenbase compiles gene-specific pages which include manually curated gene expression images, functional information including gene ontology (GO), disease associations, and links to other major data sources such as NCBI:Entrez, UniProtKB, and Ensembl. We also maintain the Xenopus Anatomy Ontology (XAO) which describes anatomy throughout embryonic development. This chapter provides a full description of the many features of Xenbase, and offers a guide on how to use various tools to perform a variety of common tasks such as identifying nucleic acid or protein sequences, finding gene expression patterns for specific genes, stages or tissues, identifying literature on a specific gene or tissue, locating useful reagents and downloading our extensive content, including Xenopus gene-Human gene disease mapping files.
Ahmed,
A Database of microRNA Expression Patterns in Xenopus laevis.
2015, Pubmed,
Xenbase
Ahmed,
A Database of microRNA Expression Patterns in Xenopus laevis.
2015,
Pubmed
,
Xenbase
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Armisen,
Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis.
2009,
Pubmed
,
Xenbase
Bauer,
The cleavage stage origin of Spemann's Organizer: analysis of the movements of blastomere clones before and during gastrulation in Xenopus.
1994,
Pubmed
,
Xenbase
Bhattacharya,
CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus.
2015,
Pubmed
,
Xenbase
Blitz,
Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.
2013,
Pubmed
,
Xenbase
Bowes,
Xenbase: a Xenopus biology and genomics resource.
2008,
Pubmed
,
Xenbase
Ciau-Uitz,
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.
2013,
Pubmed
,
Xenbase
Gilchrist,
Databases of gene expression in Xenopus development.
2012,
Pubmed
,
Xenbase
Grant,
The Xenopus ORFeome: A resource that enables functional genomics.
2015,
Pubmed
,
Xenbase
GURDON,
The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis.
1960,
Pubmed
,
Xenbase
GURDON,
Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei.
1958,
Pubmed
,
Xenbase
Heasman,
Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach.
2000,
Pubmed
,
Xenbase
Hellsten,
The genome of the Western clawed frog Xenopus tropicalis.
2010,
Pubmed
,
Xenbase
Kaminski,
Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.
2016,
Pubmed
,
Xenbase
Karimi,
The Virtual Xenbase: transitioning an online bioinformatics resource to a private cloud.
2014,
Pubmed
,
Xenbase
Khokha,
Techniques and probes for the study of Xenopus tropicalis development.
2002,
Pubmed
,
Xenbase
Knowlton,
Naming CRISPR alleles: endonuclease-mediated mutation nomenclature across species.
2017,
Pubmed
Matsuda,
A New Nomenclature of Xenopus laevis Chromosomes Based on the Phylogenetic Relationship to Silurana/Xenopus tropicalis.
2015,
Pubmed
,
Xenbase
Mi,
Large-scale gene function analysis with the PANTHER classification system.
2013,
Pubmed
Moody,
Fates of the blastomeres of the 32-cell-stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 16-cell stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Nasevicius,
Effective targeted gene 'knockdown' in zebrafish.
2000,
Pubmed
Nutt,
Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis.
2001,
Pubmed
,
Xenbase
Owens,
Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development.
2016,
Pubmed
,
Xenbase
Parain,
A large scale screen for neural stem cell markers in Xenopus retina.
2012,
Pubmed
,
Xenbase
Raciti,
Organization of the pronephric kidney revealed by large-scale gene expression mapping.
2008,
Pubmed
,
Xenbase
Rana,
Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides.
2006,
Pubmed
,
Xenbase
Raney,
Track data hubs enable visualization of user-defined genome-wide annotations on the UCSC Genome Browser.
2014,
Pubmed
Sater,
Using Xenopus to understand human disease and developmental disorders.
2017,
Pubmed
,
Xenbase
Segerdell,
Enhanced XAO: the ontology of Xenopus anatomy and development underpins more accurate annotation of gene expression and queries on Xenbase.
2013,
Pubmed
,
Xenbase
Segerdell,
An ontology for Xenopus anatomy and development.
2008,
Pubmed
,
Xenbase
Session,
Genome evolution in the allotetraploid frog Xenopus laevis.
2016,
Pubmed
,
Xenbase
Skinner,
JBrowse: a next-generation genome browser.
2009,
Pubmed
Vize,
Database and Informatic Challenges in Representing Both Diploid and Tetraploid Xenopus Species in Xenbase.
2015,
Pubmed
,
Xenbase
Yanai,
Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility.
2011,
Pubmed
,
Xenbase
Zahn,
The Zahn drawings: new illustrations of Xenopus embryo and tadpole stages for studies of craniofacial development.
2017,
Pubmed
,
Xenbase