Sobeck A , Stone S , Costanzo V , de Graaf B , Reuter T , de Winter J , Wallisch M , Akkari Y , Olson S , Wang W , Joenje H , Christian JL , Lupardus PJ , Cimprich KA , Gautier J , Hoatlin ME .

CA092245 NCI NIH HHS , CA112775 NCI NIH HHS , GM62193 NIGMS NIH HHS , R03 HD050242 NICHD NIH HHS , R01 GM062193 NIGMS NIH HHS , R01 CA092245 NCI NIH HHS , R01 CA112775 NCI NIH HHS

             DNA damage checkpoint
             DNA repair
             G1/S transition checkpoint
             Fanconi anaemia nuclear complex
             regulation of DNA stability

                Fanconi anemia
                bone marrow disease

           FANCONI ANEMIA, COMPLEMENTATION GROUP A; FANCA

Andreassen, ATR couples FANCD2 monoubiquitination to the DNA-damage response. 2004, Pubmed

Andreassen, ATR couples FANCD2 monoubiquitination to the DNA-damage response. 2004, Pubmed
Ball, ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. 2005, Pubmed
Ball, ATRIP oligomerization is required for ATR-dependent checkpoint signaling. 2005, Pubmed
Bartek, Mammalian G1- and S-phase checkpoints in response to DNA damage. 2001, Pubmed
Bessho, Induction of DNA replication-mediated double strand breaks by psoralen DNA interstrand cross-links. 2003, Pubmed
Bomgarden, A novel protein activity mediates DNA binding of an ATR-ATRIP complex. 2004, Pubmed
Bridge, The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. 2005, Pubmed
Byun, Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. 2005, Pubmed , Xenbase
Canman, Checkpoint mediators: relaying signals from DNA strand breaks. 2003, Pubmed
Chen, BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. 1999, Pubmed
Cortez, ATR and ATRIP: partners in checkpoint signaling. 2001, Pubmed
Costanzo, Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. 2003, Pubmed
Costanzo, Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. 2001, Pubmed , Xenbase
Costanzo, Protein kinase A is required for chromosomal DNA replication. 1999, Pubmed , Xenbase
Costanzo, An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. 2003, Pubmed , Xenbase
Costanzo, Xenopus cell-free extracts to study DNA damage checkpoints. 2004, Pubmed , Xenbase
Costanzo, Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. 2000, Pubmed , Xenbase
D'Andrea, The Fanconi anaemia/BRCA pathway. 2003, Pubmed
D'Andrea, Molecular biology of Fanconi anemia: implications for diagnosis and therapy. 1997, Pubmed
Davies, Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. 2001, Pubmed
De Silva, Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. 2000, Pubmed
de Winter, The Fanconi anaemia group G gene FANCG is identical with XRCC9. 1998, Pubmed
de Winter, The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. 2000, Pubmed
de Winter, The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. 2000, Pubmed
de Winter, Isolation of a cDNA representing the Fanconi anemia complementation group E gene. 2000, Pubmed
Donahue, Deficient regulation of DNA double-strand break repair in Fanconi anemia fibroblasts. 2003, Pubmed
Donahue, A DNA double strand break repair defect in Fanconi anemia fibroblasts. 2002, Pubmed
Dronkert, Repair of DNA interstrand cross-links. 2001, Pubmed
Enomoto, Functions of RecQ family helicases: possible involvement of Bloom's and Werner's syndrome gene products in guarding genome integrity during DNA replication. 2001, Pubmed
Falck, Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. 2005, Pubmed
Franchitto, Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery. 2004, Pubmed
Franchitto, Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. 2002, Pubmed
Franchitto, Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex. 2002, Pubmed
Garcia-Higuera, Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. 2001, Pubmed
Garcia-Higuera, The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. 2000, Pubmed
Garcia-Higuera, Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. 1999, Pubmed
Grompe, Fanconi anemia and DNA repair. 2001, Pubmed
Guo, Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. 2000, Pubmed , Xenbase
Hekmat-Nejad, Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. , Pubmed , Xenbase
Hirano, Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM. 2005, Pubmed
Hölzel, FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia. 2003, Pubmed
Howlett, Biallelic inactivation of BRCA2 in Fanconi anemia. 2002, Pubmed
Howlett, The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. 2005, Pubmed
Hussain, Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. 2004, Pubmed
Itakura, ATR-dependent phosphorylation of ATRIP in response to genotoxic stress. 2004, Pubmed
Itakura, Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage. 2004, Pubmed
Jasin, Homologous repair of DNA damage and tumorigenesis: the BRCA connection. 2002, Pubmed
Joenje, The emerging genetic and molecular basis of Fanconi anaemia. 2001, Pubmed
Kobayashi, Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract. 2002, Pubmed , Xenbase
Komori, Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks. 2004, Pubmed
Lee, Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. 2004, Pubmed
Levitus, The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. 2005, Pubmed
Levran, The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. 2005, Pubmed
Li, Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases. 2004, Pubmed , Xenbase
Lo Ten Foe, Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. 1996, Pubmed
Luciani, Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus. 2004, Pubmed , Xenbase
Lupardus, A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. 2002, Pubmed , Xenbase
Medhurst, Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. 2001, Pubmed
Meetei, A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. 2003, Pubmed
Meetei, FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination. 2004, Pubmed
Meetei, A novel ubiquitin ligase is deficient in Fanconi anemia. 2003, Pubmed
Meetei, A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. 2005, Pubmed
Mi, The Fanconi anemia core complex associates with chromatin during S phase. 2005, Pubmed
Montes de Oca, Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. 2005, Pubmed
Mosedale, The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. 2005, Pubmed
Murray, Cell cycle extracts. 1991, Pubmed
Nakanishi, Interaction of FANCD2 and NBS1 in the DNA damage response. 2002, Pubmed
Nakanishi, Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. 2005, Pubmed
Niedzwiedz, The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. 2004, Pubmed
Nishino, Structural and functional analyses of an archaeal XPF/Rad1/Mus81 nuclease: asymmetric DNA binding and cleavage mechanisms. 2005, Pubmed
Nishino, Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing. 2005, Pubmed
Nyberg, Toward maintaining the genome: DNA damage and replication checkpoints. 2002, Pubmed
Pacek, A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. 2004, Pubmed , Xenbase
Pasero, Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets. 2003, Pubmed
Pichierri, Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication? 2004, Pubmed
Pichierri, The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. 2004, Pubmed
Pichierri, DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. 2002, Pubmed
Powell, Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation. 2003, Pubmed
Qiao, Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner. 2001, Pubmed
Robertson, Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development. 1999, Pubmed , Xenbase
Rothfuss, Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. 2004, Pubmed
Saleh-Gohari, Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. 2004, Pubmed
Sarkaria, Identifying inhibitors of ATM and ATR kinase activities. 2003, Pubmed
Shechter, ATR and ATM regulate the timing of DNA replication origin firing. 2004, Pubmed , Xenbase
Stokes, DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. 2002, Pubmed , Xenbase
Strathdee, Cloning of cDNAs for Fanconi's anaemia by functional complementation. 1992, Pubmed
Tada, Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. 2001, Pubmed , Xenbase
Taniguchi, S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. 2002, Pubmed
Taniguchi, Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 2002, Pubmed
Tercero, A central role for DNA replication forks in checkpoint activation and response. 2003, Pubmed
Thompson, How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery. 2005, Pubmed
Timmers, Positional cloning of a novel Fanconi anemia gene, FANCD2. 2001, Pubmed
Unsal-Kaçmaz, Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. 2004, Pubmed
Venkitaraman, A growing network of cancer-susceptibility genes. 2003, Pubmed
Waisfisz, A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. 1999, Pubmed
Walter, Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. 2000, Pubmed , Xenbase
Wang, Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. 2004, Pubmed
Wu, The Bloom's syndrome helicase suppresses crossing over during homologous recombination. 2003, Pubmed
Yamamoto, Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. 2003, Pubmed
Yamamoto, Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. 2005, Pubmed
You, The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. 2002, Pubmed , Xenbase
Zou, Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. 2003, Pubmed