Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-40802
Proteomics 2010 Feb 01;103:574-80. doi: 10.1002/pmic.200900281.
Show Gene links Show Anatomy links

A proteome map of the pituitary melanotrope cell activated by black-background adaptation of Xenopus laevis.

Sergeant K , Van Bakel NH , Debyser G , Van Beeumen J , Martens GJ , Van Herp F .


???displayArticle.abstract???
Upon transfer of Xenopus laevis from a white to a black background, the melanotrope cells in the pituitary pars intermedia secrete alpha-melanocyte-stimulating hormone, which stimulates dispersion of melanin pigment in skin melanophores. This adaptive behavior is under the control of neurotransmitters and neuropeptides of hypothalamic origin. The alpha-melanocyte-stimulating hormone-producing cells and their hypothalamic control system provide an interesting model to study proteins required for biosynthetic and secretory processes involved in peptide hormone production and for brain-pituitary signaling. We present a 2-D PAGE-based proteome map of melanotrope cells from black-adapted animals, identifying 204 different proteins by MS analysis.

???displayArticle.pubmedLink??? 20029839
???displayArticle.link??? Proteomics