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Dev Cell
2014 Dec 08;315:599-613. doi: 10.1016/j.devcel.2014.10.012.
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Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain.
Herrgen L
,
Voss OP
,
Akerman CJ
.
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Both developing and adult organisms need efficient strategies for wound repair. In adult mammals, wounding triggers an inflammatory response that can exacerbate tissue injury and lead to scarring. In contrast, embryonic wounds heal quickly and with minimal inflammation, but how this is achieved remains incompletely understood. Using in vivo imaging in the developing brain of Xenopus laevis, we show that ATP release from damaged cells and subsequent activation of purinergic receptors induce long-range calcium waves in neural progenitor cells. Cytoskeletal reorganization and activation of the actomyosin contractile machinery in a Rho kinase-dependent manner then lead to rapid and pronounced apical-basal contractions of the neuroepithelium. These contractions drive the expulsion of damaged cells into the brain ventricle within seconds. Successful cell expulsion prevents the death of nearby cells and an exacerbation of the injury. Cell expulsion through neuroepithelial contraction represents a mechanism for rapid wound healing in the developing brain.
Abbracchio,
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.
2006, Pubmed
Abbracchio,
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.
2006,
Pubmed
Andrade,
Apoptotic regulation of epithelial cellular extrusion.
2011,
Pubmed
Baethmann,
Fetal CNS damage after exposure to maternal trauma during pregnancy.
1996,
Pubmed
Bement,
Wound-induced assembly and closure of an actomyosin purse string in Xenopus oocytes.
1999,
Pubmed
,
Xenbase
Bement,
A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance.
1993,
Pubmed
Benink,
Concentric zones of active RhoA and Cdc42 around single cell wounds.
2005,
Pubmed
,
Xenbase
Bielefeld,
Cutaneous wound healing: recruiting developmental pathways for regeneration.
2013,
Pubmed
Burkel,
Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophin.
2007,
Pubmed
,
Xenbase
Calegari,
Neurodevelopment. Tossed out to save the masses.
2014,
Pubmed
,
Xenbase
Clark,
Integration of single and multicellular wound responses.
2009,
Pubmed
,
Xenbase
Cordeiro,
The role of transcription-independent damage signals in the initiation of epithelial wound healing.
2013,
Pubmed
Corrigall,
Hedgehog signaling is a principal inducer of Myosin-II-driven cell ingression in Drosophila epithelia.
2007,
Pubmed
Crosby,
Epithelial repair mechanisms in the lung.
2010,
Pubmed
Degen,
Embryonic wound healing: a primer for engineering novel therapies for tissue repair.
2012,
Pubmed
Gu,
Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.
2011,
Pubmed
Gurtner,
Wound repair and regeneration.
2008,
Pubmed
Halfter,
Effect of wound healing and tissue transplantation on the navigation of axons in organ-cultured embryonic chick eyes.
1993,
Pubmed
Hayes,
Cerebral palsy after maternal trauma in pregnancy.
2007,
Pubmed
Joshi,
Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction.
2010,
Pubmed
,
Xenbase
Khakh,
International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
2001,
Pubmed
Kroemer,
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.
2009,
Pubmed
Krysko,
Clearance of apoptotic and necrotic cells and its immunological consequences.
2006,
Pubmed
Larson,
Scarless fetal wound healing: a basic science review.
2010,
Pubmed
Lawson,
The effect of embryonic cerebrospinal fluid pressure and morphogenetic brain expansion on wound healing in the midbrain of the chick embryo.
1996,
Pubmed
Lawson,
Studies on wound healing in the neuroepithelium of the chick embryo.
1992,
Pubmed
Lázár,
The development of the optic tectum in Xenopus laevis: a Golgi study.
1973,
Pubmed
,
Xenbase
Leroy-Malherbe,
The association between developmental handicaps and traumatic brain injury during pregnancy: an issue that deserves more systematic evaluation.
2006,
Pubmed
Liu,
Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors.
2010,
Pubmed
Lo,
Scarless fetal skin wound healing update.
2012,
Pubmed
Martin,
Inflammatory cells during wound repair: the good, the bad and the ugly.
2005,
Pubmed
Martin,
Actin cables and epidermal movement in embryonic wound healing.
1992,
Pubmed
Martin,
Pulsed contractions of an actin-myosin network drive apical constriction.
2009,
Pubmed
McCluskey,
Analysis of the tissue movements of embryonic wound healing--DiI studies in the limb bud stage mouse embryo.
1995,
Pubmed
Naik-Mathuria,
Age-dependent recruitment of neutrophils by fetal endothelial cells: implications in scarless wound healing.
2007,
Pubmed
Novo,
Redox mechanisms in hepatic chronic wound healing and fibrogenesis.
2008,
Pubmed
Pearson,
ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation.
2005,
Pubmed
Rauzi,
Planar polarized actomyosin contractile flows control epithelial junction remodelling.
2010,
Pubmed
Razzell,
Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release.
2013,
Pubmed
Riento,
Rocks: multifunctional kinases in cell behaviour.
2003,
Pubmed
Rosenblatt,
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism.
2001,
Pubmed
Sauzeau,
P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes.
2000,
Pubmed
Sherrard,
Sequential activation of apical and basolateral contractility drives ascidian endoderm invagination.
2010,
Pubmed
Sieger,
Long-range Ca2+ waves transmit brain-damage signals to microglia.
2012,
Pubmed
Siehler,
Regulation of RhoGEF proteins by G12/13-coupled receptors.
2009,
Pubmed
Singer,
Cutaneous wound healing.
1999,
Pubmed
Sonnemann,
Wound repair: toward understanding and integration of single-cell and multicellular wound responses.
2011,
Pubmed
Soto,
Inositol kinase and its product accelerate wound healing by modulating calcium levels, Rho GTPases, and F-actin assembly.
2013,
Pubmed
,
Xenbase
Straight,
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.
2003,
Pubmed
Straznicky,
The development of the tectum in Xenopus laevis: an autoradiographic study.
1972,
Pubmed
,
Xenbase
Wallingford,
Calcium signaling during convergent extension in Xenopus.
2001,
Pubmed
,
Xenbase
Weissman,
Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex.
2004,
Pubmed
Whitby,
Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin.
1991,
Pubmed
