Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Anat
2011 Feb 01;2182:226-42. doi: 10.1111/j.1469-7580.2010.01315.x.
Show Gene links
Show Anatomy links
A role for FoxN3 in the development of cranial cartilages and muscles in Xenopus laevis (Amphibia: Anura: Pipidae) with special emphasis on the novel rostral cartilages.
???displayArticle.abstract???
The origin of morphological novelties is a controversial topic in evolutionary developmental biology. The heads of anuran larvae have several unique structures, including the supra- and infrarostral cartilages, the specialised structure of the gill basket (used for filtration), and novel cranial muscle arrangements. FoxN3, a member of the forkhead/winged helix family of transcription factors, has been implicated as important for normal craniofacial development in the pipid anuran Xenopus laevis. We have investigated the effects of functional knockdown of FoxN3 (using antisense oligonucleotide morpholino) on the development of the larval head skeleton and the associated cranial muscles in X. laevis. Our data complement earlier studies and provide a more complete account of the requirement of FoxN3 in chondrocranium development. In addition, we analyse the effects of FoxN3 knockdown on cranial muscle development. We show that FoxN3 knockdown primarily affects the novel skeletal structures unique to anuran larvae, i.e. the rostralia or the fine structure of the gill apparatus. The articulation between the infrarostral and Meckel's cartilage is malformed and the filigreed processes of the gill basket do not develop. Because these features do not develop after FoxN3 knockdown, the head morphology resembles that in the less specialised larvae of salamanders. Furthermore, the development of all cartilages derived from the neural crest is delayed and cranial muscle fibre development incomplete. The cartilage precursors initially condense in their proper position but later differentiate incompletely; several visceral arch muscles start to differentiate at their origin but fail to extend toward their insertion. Our findings indicate that FoxN3 is essential for the development of novel cartilages such as the infrarostral and other cranial tissues derived from the neural crest and, indirectly, also for muscle morphogenesis.
Ayer,
Histone deacetylases: transcriptional repression with SINers and NuRDs.
1999, Pubmed
Ayer,
Histone deacetylases: transcriptional repression with SINers and NuRDs.
1999,
Pubmed
Barembaum,
Early steps in neural crest specification.
2005,
Pubmed
,
Xenbase
Cerny,
Developmental origins and evolution of jaws: new interpretation of "maxillary" and "mandibular".
2004,
Pubmed
Couly,
The developmental fate of the cephalic mesoderm in quail-chick chimeras.
1992,
Pubmed
De Sá,
Development of the suprarostral plate of pipoid frogs.
1999,
Pubmed
,
Xenbase
Dottori,
The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate.
2001,
Pubmed
Epperlein,
The ectomesenchymal-endodermal interaction-system (EEIS) of Triturus alpestris in tissue culture. I. Observations on attachment, migration and differentiation of neural crest cells.
1974,
Pubmed
Ericsson,
Role of cranial neural crest cells in visceral arch muscle positioning and morphogenesis in the Mexican axolotl, Ambystoma mexicanum.
2004,
Pubmed
,
Xenbase
Ericsson,
Patterns of spatial and temporal visceral arch muscle development in the Mexican axolotl (Ambystoma mexicanum).
2004,
Pubmed
Evans,
Spatial relations between avian craniofacial neural crest and paraxial mesoderm cells.
2006,
Pubmed
Francis-West,
Signalling interactions during facial development.
1998,
Pubmed
Gómez-Skarmeta,
Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development.
1999,
Pubmed
,
Xenbase
Graham,
Neural Crest Apoptosis and the Establishment of Craniofacial Pattern: An Honorable Death.
1996,
Pubmed
Graham,
Neural crest apoptosis and the establishment of craniofacial pattern: an honorable death.
1996,
Pubmed
Graham,
Patterning the pharyngeal arches.
2001,
Pubmed
Gross,
Segmentation of the vertebrate skull: neural-crest derivation of adult cartilages in the clawed frog, Xenopus laevis.
2008,
Pubmed
,
Xenbase
Hall,
The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis.
1992,
Pubmed
Hong,
Sox proteins and neural crest development.
2005,
Pubmed
Kintner,
Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.
,
Pubmed
,
Xenbase
Köntges,
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny.
1996,
Pubmed
Kuraku,
Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates.
2010,
Pubmed
Kuratani,
Developmental studies of the lamprey and hierarchical evolutionary steps towards the acquisition of the jaw.
2005,
Pubmed
Kuratani,
Evolution of the vertebrate jaw: comparative embryology and molecular developmental biology reveal the factors behind evolutionary novelty.
2004,
Pubmed
Marks,
Histone deacetylase inhibitors as new cancer drugs.
2001,
Pubmed
Maurus,
Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis.
2005,
Pubmed
,
Xenbase
McClearn,
Ontogeny of architectural complexity in embryonic quail visceral arch muscles.
1988,
Pubmed
Metscher,
MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues.
2009,
Pubmed
Miller,
Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint.
2003,
Pubmed
Minucci,
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
2006,
Pubmed
Newman,
Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle.
1997,
Pubmed
,
Xenbase
Newman,
The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut.
1999,
Pubmed
,
Xenbase
Noden,
The differentiation and morphogenesis of craniofacial muscles.
2006,
Pubmed
Noden,
The embryonic origins of avian cephalic and cervical muscles and associated connective tissues.
1983,
Pubmed
Noden,
Relations and interactions between cranial mesoderm and neural crest populations.
2005,
Pubmed
Noden,
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues.
1983,
Pubmed
Olsson,
Cranial neural-crest migration and chondrogenic fate in the oriental fire-bellied toad Bombina orientalis: Defining the ancestral pattern of head development in anuran amphibians.
1996,
Pubmed
Olsson,
Cranial neural crest cells contribute to connective tissue in cranial muscles in the anuran amphibian, Bombina orientalis.
2001,
Pubmed
Pati,
Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.
1997,
Pubmed
Piekarski,
Muscular derivatives of the cranialmost somites revealed by long-term fate mapping in the Mexican axolotl (Ambystoma mexicanum).
2007,
Pubmed
Pillai,
Histone deacetylase 1 (HDAC-1) required for the normal formation of craniofacial cartilage and pectoral fins of the zebrafish.
2004,
Pubmed
Pitsillides,
A critical evaluation of specific aspects of joint development.
2008,
Pubmed
Rinon,
Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.
2007,
Pubmed
Sadaghiani,
Neural crest development in the Xenopus laevis embryo, studied by interspecific transplantation and scanning electron microscopy.
1987,
Pubmed
,
Xenbase
Samaan,
Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
2010,
Pubmed
Santagati,
Cranial neural crest and the building of the vertebrate head.
2003,
Pubmed
Sato,
Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm.
2005,
Pubmed
,
Xenbase
Schilling,
Musculoskeletal patterning in the pharyngeal segments of the zebrafish embryo.
1997,
Pubmed
Schneider,
Neural crest can form cartilages normally derived from mesoderm during development of the avian head skeleton.
1999,
Pubmed
Schuff,
FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis.
2010,
Pubmed
,
Xenbase
Schuff,
FoxN3 is required for craniofacial and eye development of Xenopus laevis.
2007,
Pubmed
,
Xenbase
Schuff,
Temporal and spatial expression patterns of FoxN genes in Xenopus laevis embryos.
2006,
Pubmed
,
Xenbase
Scott,
Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae.
2003,
Pubmed
Seufert,
Tissue interactions involving cranial neural crest in cartilage formation in Xenopus laevis (Daudin).
1990,
Pubmed
,
Xenbase
Shigetani,
Heterotopic shift of epithelial-mesenchymal interactions in vertebrate jaw evolution.
2002,
Pubmed
Sokol,
The free swimming Pipa larvae, with a review of pipid larvae and pipid phylogeny (Anura: Pipidae).
1977,
Pubmed
,
Xenbase
Svensson,
Evolutionary innovation in the vertebrate jaw: A derived morphology in anuran tadpoles and its possible developmental origin.
2005,
Pubmed
,
Xenbase
Tokita,
Developmental origins of species-specific muscle pattern.
2009,
Pubmed
Trainor,
Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches.
1995,
Pubmed
Tribioli,
Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe.
1997,
Pubmed
Tribioli,
Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton.
1997,
Pubmed
Trueb,
Skeletal development in Xenopus laevis (Anura: Pipidae).
1992,
Pubmed
,
Xenbase
Umansky,
The effect of cell population density on the developmental fate of reaggregating mouse limb bud mesenchyme.
1966,
Pubmed
Wilson,
Fgf and Bmp signals repress the expression of Bapx1 in the mandibular mesenchyme and control the position of the developing jaw joint.
2004,
Pubmed
Ziermann,
Patterns of spatial and temporal cranial muscle development in the African clawed frog, Xenopus laevis (Anura: Pipidae).
2007,
Pubmed
,
Xenbase
