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Cheng SK
,
Olale F
,
Bennett JT
,
Brivanlou AH
,
Schier AF
.
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The TGF-beta signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously.
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12514096
???displayArticle.pmcLink???PMC195969 ???displayArticle.link???Genes Dev ???displayArticle.grants???[+]
Bamford,
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
2000, Pubmed
Bamford,
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
2000,
Pubmed
Bianco,
Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.
2002,
Pubmed
Brennan,
Nodal activity in the node governs left-right asymmetry.
2002,
Pubmed
Conlon,
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse.
1994,
Pubmed
Ding,
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
1998,
Pubmed
Feldman,
Zebrafish organizer development and germ-layer formation require nodal-related signals.
1998,
Pubmed
Gaio,
A role of the cryptic gene in the correct establishment of the left-right axis.
1999,
Pubmed
Gritsman,
The EGF-CFC protein one-eyed pinhead is essential for nodal signaling.
1999,
Pubmed
,
Xenbase
Hata,
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
2000,
Pubmed
,
Xenbase
Hemmati-Brivanlou,
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos.
1992,
Pubmed
,
Xenbase
Hyatt,
The left-right coordinator: the role of Vg1 in organizing left-right axis formation.
1998,
Pubmed
,
Xenbase
Hyatt,
Initiation of vertebrate left-right axis formation by maternal Vg1.
1996,
Pubmed
,
Xenbase
Kessler,
Induction of dorsal mesoderm by soluble, mature Vg1 protein.
1995,
Pubmed
,
Xenbase
Lee,
Timing of endogenous activin-like signals and regional specification of the Xenopus embryo.
2001,
Pubmed
,
Xenbase
Lowe,
Genetic dissection of nodal function in patterning the mouse embryo.
2001,
Pubmed
Massagué,
Controlling TGF-beta signaling.
2000,
Pubmed
Norris,
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
2002,
Pubmed
Ramsdell,
Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway.
1999,
Pubmed
,
Xenbase
Rankin,
Regulation of left-right patterning in mice by growth/differentiation factor-1.
2000,
Pubmed
Reissmann,
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
2001,
Pubmed
,
Xenbase
Sakuma,
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.
2002,
Pubmed
,
Xenbase
Saloman,
The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.
2000,
Pubmed
,
Xenbase
Sampath,
Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.
1998,
Pubmed
,
Xenbase
Schier,
Nodal signalling in vertebrate development.
2000,
Pubmed
Seleiro,
Early developmental expression and experimental axis determination by the chicken Vg1 gene.
1996,
Pubmed
,
Xenbase
Shen,
The EGF-CFC gene family in vertebrate development.
2000,
Pubmed
Shen,
A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation.
1997,
Pubmed
,
Xenbase
Skromne,
A hierarchy of gene expression accompanying induction of the primitive streak by Vg1 in the chick embryo.
2002,
Pubmed
Thomsen,
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
1993,
Pubmed
,
Xenbase
Wall,
Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene.
2000,
Pubmed
,
Xenbase
Weeks,
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.
1987,
Pubmed
,
Xenbase
Whitman,
Nodal signaling in early vertebrate embryos: themes and variations.
2001,
Pubmed
,
Xenbase
Yan,
Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.
1999,
Pubmed
Yan,
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.
2002,
Pubmed
Yeo,
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.
2001,
Pubmed
,
Xenbase
Zhang,
Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation.
1998,
Pubmed
Zimmerman,
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
1996,
Pubmed
,
Xenbase
