Zeng X , Sigoillot F , Gaur S , Choi S , Pfaff KL , Oh DC , Hathaway N , Dimova N , Cuny GD , King RW .

CA089393 NCI NIH HHS , GM085923 NIGMS NIH HHS , GM66492 NIGMS NIH HHS , R01 GM066492-06A1 NIGMS NIH HHS , R01 GM066492-07 NIGMS NIH HHS , R01 GM066492-07S1 NIGMS NIH HHS , R01 GM066492-08 NIGMS NIH HHS , R01 GM066492-09 NIGMS NIH HHS , R56 GM066492-06 NIGMS NIH HHS , R01 GM066492 NIGMS NIH HHS , R56 GM066492 NIGMS NIH HHS

Bekier, Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. 2009, Pubmed

Bekier, Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. 2009, Pubmed
Biggins, The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. 2001, Pubmed
Brito, Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. 2006, Pubmed
Brito, Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied. 2008, Pubmed
Burton, Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box. 2005, Pubmed
Cheeseman, The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. 2006, Pubmed
Choi, BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis. 2009, Pubmed
Chung, Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint. 2003, Pubmed , Xenbase
Clute, Temporal and spatial control of cyclin B1 destruction in metaphase. 1999, Pubmed
D'Angiolella, The spindle checkpoint requires cyclin-dependent kinase activity. 2003, Pubmed , Xenbase
DeLuca, Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. 2006, Pubmed
den Elzen, Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. 2001, Pubmed
Engelbert, The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. 2008, Pubmed
Famulski, Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores. 2007, Pubmed
Gascoigne, Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. 2008, Pubmed
Ge, APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. 2009, Pubmed
Hauf, The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. 2003, Pubmed
Hayes, Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C. 2006, Pubmed , Xenbase
Hsu, E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). 2002, Pubmed , Xenbase
Huang, Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. 2009, Pubmed
Kimata, A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment. 2008, Pubmed , Xenbase
Kirkpatrick, Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. 2006, Pubmed
Kraft, The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. 2005, Pubmed
Matyskiela, Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. 2009, Pubmed
Minshull, A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. 1994, Pubmed , Xenbase
Montero, Docetaxel for treatment of solid tumours: a systematic review of clinical data. 2005, Pubmed
Musacchio, The spindle-assembly checkpoint in space and time. 2007, Pubmed
Nilsson, The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction. 2008, Pubmed
Ohi, Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. 2007, Pubmed
Orth, Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. 2008, Pubmed
Palframan, Anaphase inactivation of the spindle checkpoint. 2006, Pubmed
Peters, The anaphase promoting complex/cyclosome: a machine designed to destroy. 2006, Pubmed
Qi, KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. 2007, Pubmed
Reddy, Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. 2007, Pubmed
Schwab, Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. 2001, Pubmed
Shi, Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. 2008, Pubmed
Sigl, Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. 2009, Pubmed
Stegmeier, Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. 2007, Pubmed
Stewart, Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. 2005, Pubmed
Thornton, An architectural map of the anaphase-promoting complex. 2006, Pubmed
Verma, Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. 2004, Pubmed , Xenbase
Visconti, Requirement for proteolysis in spindle assembly checkpoint silencing. 2010, Pubmed
Vodermaier, TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. 2003, Pubmed
Welburn, Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. 2010, Pubmed
Wójcik, An inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces arrest in G2-phase and metaphase in HeLa cells. 1996, Pubmed
Wolthuis, Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A. 2008, Pubmed
Yu, Cdc20: a WD40 activator for a cell cycle degradation machine. 2007, Pubmed