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XB-ART-51734
Dev Cell 2015 Sep 28;346:609-10. doi: 10.1016/j.devcel.2015.09.010.
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Kinesin-5: A Team Is Just the Sum of Its Parts.

Hueschen CL , Long AF , Dumont S .


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How the cell builds a spindle remains an open question. In this issue of Developmental Cell, Shimamoto, Forth, and Kapoor (2015) show that kinesin-5 motor ensembles can exert sliding forces that scale with microtubule overlap length. This behavior could allow microtubule architecture-dependent modulation of force and contribute to spindle self-organization.

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Species referenced: Xenopus laevis

References :
Shimamoto, Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules. 2015, Pubmed, Xenbase