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The dynamics of the Aurora B protein kinase during Xenopus oocyte meiotic maturation were examined. Resting G2 oocytes express inactive Aurora B that is not associated with other subunits of the chromosome passenger complex (CPC). Activity increases near the time of germinal vesicle breakdown in progesterone-treated oocytes, and this increase is correlated with the synthesis of inner centromere protein (INCENP) and survivin, components of the CPC. Ablation of INCENP synthesis led to the failure of progesterone treatment to activate Aurora B, but biochemical progression through the meiosis I-to-II transition and arrest at metaphase II were not affected. At fertilization, Aurora B was deactivated in concert with the degradation of INCENP, and the levels of Aurora B kinase activity and INCENP oscillated in subsequent embryonic cell cycles. Prevention of the decrease in Aurora B activity at fertilization by expression of ectopic wild-type INCENP, but not kinase-dead Aurora BINCENP, blocked calcium-induced exit from metaphase arrest in egg extracts.
Andreassen,
Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.
1991, Pubmed
Andreassen,
Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.
1991,
Pubmed
Andrews,
Mitotic mechanics: the auroras come into view.
2003,
Pubmed
,
Xenbase
Bayliss,
Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.
2004,
Pubmed
,
Xenbase
Bishop,
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity.
2002,
Pubmed
Bolton,
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation.
2002,
Pubmed
,
Xenbase
Carmena,
The cellular geography of aurora kinases.
2003,
Pubmed
,
Xenbase
Ducat,
Aurora kinases in spindle assembly and chromosome segregation.
2004,
Pubmed
Egloff,
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.
1997,
Pubmed
Eyers,
The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.
2005,
Pubmed
,
Xenbase
Eyers,
A novel mechanism for activation of the protein kinase Aurora A.
2003,
Pubmed
,
Xenbase
Gadea,
Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.
2005,
Pubmed
,
Xenbase
Gassmann,
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.
2004,
Pubmed
Grimison,
Metaphase arrest by cyclin E-Cdk2 requires the spindle-checkpoint kinase Mps1.
2006,
Pubmed
,
Xenbase
Haccard,
Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase.
1993,
Pubmed
,
Xenbase
Honda,
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.
2003,
Pubmed
Inoue,
A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.
2007,
Pubmed
,
Xenbase
Jelínková,
Neither Aurora B activity nor histone H3 phosphorylation is essential for chromosome condensation during meiotic maturation of porcine oocytes.
2006,
Pubmed
Kaitna,
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis.
2002,
Pubmed
Kang,
Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation.
2001,
Pubmed
Liu,
Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor.
2005,
Pubmed
,
Xenbase
Lorca,
Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts.
1998,
Pubmed
,
Xenbase
Ma,
Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes.
2003,
Pubmed
,
Xenbase
Maton,
Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes.
2003,
Pubmed
,
Xenbase
Meraldi,
Aurora kinases link chromosome segregation and cell division to cancer susceptibility.
2004,
Pubmed
Monje-Casas,
Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex.
2007,
Pubmed
Murnion,
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation.
2001,
Pubmed
,
Xenbase
Nguyen,
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property.
2005,
Pubmed
Nishiyama,
Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs.
2007,
Pubmed
,
Xenbase
Parra,
Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.
2003,
Pubmed
Ramadan,
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
2007,
Pubmed
,
Xenbase
Resnick,
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
2006,
Pubmed
Ruchaud,
Chromosomal passengers: conducting cell division.
2007,
Pubmed
Sampath,
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.
2004,
Pubmed
,
Xenbase
Satinover,
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein.
2004,
Pubmed
,
Xenbase
Schmidt,
Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.
2005,
Pubmed
,
Xenbase
Schumacher,
AIR-2: An Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos.
1998,
Pubmed
Sessa,
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.
2005,
Pubmed
,
Xenbase
Stewart,
Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.
2005,
Pubmed
Stukenberg,
Systematic identification of mitotic phosphoproteins.
1997,
Pubmed
,
Xenbase
Sugiyama,
Aurora-B associated protein phosphatases as negative regulators of kinase activation.
2002,
Pubmed
Tang,
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.
2006,
Pubmed
Tung,
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.
2005,
Pubmed
,
Xenbase
Tunquist,
The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor.
2002,
Pubmed
,
Xenbase
Tunquist,
Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.
2003,
Pubmed
,
Xenbase
Vigneron,
Kinetochore localization of spindle checkpoint proteins: who controls whom?
2004,
Pubmed
,
Xenbase
Yasui,
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.
2004,
Pubmed
Yu,
The Aurora kinase Ipl1 maintains the centromeric localization of PP2A to protect cohesin during meiosis.
2007,
Pubmed
