Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-30274
Science 1983 Mar 18;2194590:1341-3.
Show Gene links Show Anatomy links

Methoxyindoles and photoreceptor metabolism: activation of rod shedding.

Besharse JC , Dunis DA .


???displayArticle.abstract???
Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.

???displayArticle.pubmedLink??? 6828862
???displayArticle.link??? Science
???displayArticle.grants??? [+]