Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
cis-acting translational effects of the 5' noncoding region of c-myc mRNA.
Parkin N
,
Darveau A
,
Nicholson R
,
Sonenberg N
.
???displayArticle.abstract???
We have previously shown that the 5' noncoding region of mouse c-myc mRNA has a negative effect on translational efficiency in a rabbit reticulocyte lysate (A. Darveau, J. Pelletier, and N. Sonenberg, Proc. Natl. Acad. Sci. USA 82:2315-2319, 1985). We wanted to localize and characterize the inhibitory translational element(s) in the mRNA and to study its effect in other in vitro and in vivo systems. Here we report that the restrictive element is confined to a 240-nucleotide sequence of the 5' noncoding region of mouse c-myc mRNA and that this sequence acts in cis to inhibit the translation of a heterologous mRNA. In addition, we report that the cis-inhibitory effect is also exhibited in microinjected Xenopus oocytes and wheat-germ extracts but not in HeLa cell extracts. Transfection of corresponding plasmid DNA constructs into several established cell lines did not produce the cis-inhibitory effect. A model to explain these results is presented.
Adams,
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.
1983, Pubmed
Adams,
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.
1983,
Pubmed
Adams,
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice.
,
Pubmed
Baim,
A mutation allowing an mRNA secondary structure diminishes translation of Saccharomyces cerevisiae iso-1-cytochrome c.
1985,
Pubmed
Bernard,
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
1983,
Pubmed
Bishop,
The molecular genetics of cancer.
1987,
Pubmed
Butnick,
Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation.
1985,
Pubmed
Corcoran,
Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma.
1985,
Pubmed
Cory,
Activation of cellular oncogenes in hemopoietic cells by chromosome translocation.
1986,
Pubmed
Dani,
Extreme instability of myc mRNA in normal and transformed human cells.
1984,
Pubmed
Dani,
Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.
1985,
Pubmed
Darveau,
Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.
1985,
Pubmed
Eisenman,
V-myc- and c-myc-encoded proteins are associated with the nuclear matrix.
1985,
Pubmed
Erikson,
The c-myc oncogene is translocated to the involved chromosome 12 in mouse plasmacytoma.
1985,
Pubmed
Fahrlander,
Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome rearrangements in a murine plasmacytoma.
1985,
Pubmed
Godeau,
C-myc expression is dissociated from DNA synthesis and cell division in Xenopus oocyte and early embryonic development.
1986,
Pubmed
,
Xenbase
Gorman,
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
1982,
Pubmed
Graham,
A new technique for the assay of infectivity of human adenovirus 5 DNA.
1973,
Pubmed
Hann,
Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.
1984,
Pubmed
Hann,
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
1988,
Pubmed
,
Xenbase
Jones,
Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences.
1987,
Pubmed
Kaufman,
Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors.
1985,
Pubmed
Kelly,
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.
1983,
Pubmed
Krieg,
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
1984,
Pubmed
,
Xenbase
Lachman,
Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.
,
Pubmed
Laemmli,
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
1970,
Pubmed
Land,
Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.
1986,
Pubmed
Land,
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
,
Pubmed
Leder,
Translocations among antibody genes in human cancer.
1983,
Pubmed
Lee,
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus.
1982,
Pubmed
Lombardi,
Pathogenesis of Burkitt lymphoma: expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts.
1987,
Pubmed
Marcu,
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia.
1983,
Pubmed
McGarry,
The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader.
1985,
Pubmed
Mellon,
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system.
1981,
Pubmed
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Nepveu,
Contributions of transcriptional and post-transcriptional mechanisms to the regulation of c-myc expression in mouse erythroleukemia cells.
1987,
Pubmed
Nilsen,
Translational efficiency of cMyc mRNA in Burkitt lymphoma cells.
1984,
Pubmed
Pelham,
An efficient mRNA-dependent translation system from reticulocyte lysates.
1976,
Pubmed
Pelletier,
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.
1985,
Pubmed
Persson,
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene.
1984,
Pubmed
Piechaczyk,
Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors.
1985,
Pubmed
Rabbitts,
Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.
1985,
Pubmed
Ramsay,
The protein encoded by the human proto-oncogene c-myc.
1984,
Pubmed
Rose,
Inhibition of translation by poliovirus: inactivation of a specific initiation factor.
1978,
Pubmed
Saito,
Activation of the c-myc gene by translocation: a model for translational control.
1983,
Pubmed
Stone,
Definition of regions in human c-myc that are involved in transformation and nuclear localization.
1987,
Pubmed
Taub,
Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells.
1984,
Pubmed
Taylor,
Xenopus myc proto-oncogene during development: expression as a stable maternal mRNA uncoupled from cell division.
1986,
Pubmed
,
Xenbase
Watt,
Nucleotide sequence of cloned cDNA of human c-myc oncogene.
,
Pubmed
Watt,
Expression and characterization of the human c-myc DNA-binding protein.
1985,
Pubmed
Wiman,
Activation of a translocated c-myc gene: role of structural alterations in the upstream region.
1984,
Pubmed
Yang,
The first exon of the c-myc proto-oncogene contains a novel positive control element.
1986,
Pubmed
