Philpott A , Yew PR .

BB/C004108/1 Biotechnology and Biological Sciences Research Council , G050010 Medical Research Council , GM066226 NIGMS NIH HHS , BB/C00406X/1 Biotechnology and Biological Sciences Research Council , G0500101 Medical Research Council , BB_BB/C00406X/1 Biotechnology and Biological Sciences Research Council

Aigner, A small gem with great powers: geminin keeps neural progenitors thriving. 2005, Pubmed, Xenbase

Aigner, A small gem with great powers: geminin keeps neural progenitors thriving. 2005, Pubmed , Xenbase
Bhatt, The protein kinase p90 rsk as an essential mediator of cytostatic factor activity. 1999, Pubmed , Xenbase
Blow, Cell cycle. A new check on issuing the licence. 2000, Pubmed , Xenbase
Blow, Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs. 1986, Pubmed , Xenbase
Bogan, Initiation of eukaryotic DNA replication: conservative or liberal? 2000, Pubmed
Carpenter, Role for a Xenopus Orc2-related protein in controlling DNA replication. 1996, Pubmed , Xenbase
Chen, Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. 1996, Pubmed , Xenbase
Chong, Purification of an MCM-containing complex as a component of the DNA replication licensing system. 1995, Pubmed , Xenbase
Chuang, Regulation of nuclear transport and degradation of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1. 2001, Pubmed , Xenbase
Ciechanover, Ubiquitin-mediated proteolysis: biological regulation via destruction. 2000, Pubmed
Clarke, Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. 1992, Pubmed , Xenbase
Coleman, The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. 1996, Pubmed , Xenbase
Cosgrove, Cell cycling and differentiation do not require the retinoblastoma protein during early Xenopus development. 2007, Pubmed , Xenbase
Coverley, Distinct roles for cyclins E and A during DNA replication complex assembly and activation. 2002, Pubmed
Coverley, Regulation of eukaryotic DNA replication. 1994, Pubmed
Cremisi, Cell cycle and cell fate interactions in neural development. 2003, Pubmed
Daniels, Identification of Xenopus cyclin-dependent kinase inhibitors, p16Xic2 and p17Xic3. 2004, Pubmed , Xenbase
Dasso, Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. 1990, Pubmed , Xenbase
DePamphilis, Review: nuclear structure and DNA replication. 2000, Pubmed
Destrée, Structure and expression of the Xenopus retinoblastoma gene. 1992, Pubmed , Xenbase
Diffley, Replication conrol: choreographing replication origins. 1998, Pubmed
Dunphy, The cdc25 protein contains an intrinsic phosphatase activity. 1991, Pubmed
Dunphy, The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. 1988, Pubmed , Xenbase
Fang, Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. 1998, Pubmed , Xenbase
Ferrell, Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs. 1991, Pubmed , Xenbase
Ferrell, Xenopus oocyte maturation: new lessons from a good egg. 1999, Pubmed , Xenbase
Fesquet, The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. 1993, Pubmed , Xenbase
Fotedar, Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts. 1996, Pubmed
Fujita, Cell cycle regulation of DNA replication initiation proteins in mammalian cells. 1999, Pubmed
Galaktionov, Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. 1991, Pubmed
Gautier, cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. 1991, Pubmed , Xenbase
Gautier, Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. 1988, Pubmed , Xenbase
Gautier, Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation. 1991, Pubmed , Xenbase
Gebauer, Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse. 1994, Pubmed
Gestri, Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression. 2005, Pubmed , Xenbase
Girard, Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. 1991, Pubmed
Goetz, TBX5 is required for embryonic cardiac cell cycle progression. 2006, Pubmed , Xenbase
Gotoh, Initiation of Xenopus oocyte maturation by activation of the mitogen-activated protein kinase cascade. 1995, Pubmed , Xenbase
Gross, Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk. 1999, Pubmed , Xenbase
Gross, The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90(Rsk). 2000, Pubmed , Xenbase
Haccard, Induction of Xenopus oocyte meiotic maturation by MAP kinase. 1995, Pubmed , Xenbase
Harland, Regulated replication of DNA microinjected into eggs of Xenopus laevis. 1980, Pubmed , Xenbase
Hartley, In vivo regulation of the early embryonic cell cycle in Xenopus. 1996, Pubmed , Xenbase
Hensey, A developmental timer that regulates apoptosis at the onset of gastrulation. 1997, Pubmed , Xenbase
Hershko, The ubiquitin system. 1998, Pubmed
Holloway, Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. 1993, Pubmed , Xenbase
Howard, The mitogen-activated protein kinase signaling pathway stimulates mos mRNA cytoplasmic polyadenylation during Xenopus oocyte maturation. 1999, Pubmed , Xenbase
Howe, Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation. 1995, Pubmed , Xenbase
Hubscher, Eukaryotic DNA polymerases. 2002, Pubmed
Hunt, The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo. 1992, Pubmed
Inoue, A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs. 2007, Pubmed , Xenbase
Jackson, Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. 1993, Pubmed
Jackson, Early events in DNA replication require cyclin E and are blocked by p21CIP1. 1995, Pubmed , Xenbase
Jessus, Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte. Antagonistic action of okadaic acid and 6-DMAP. 1991, Pubmed , Xenbase
King, Mitosis in transition. 1994, Pubmed
King, Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. 1996, Pubmed , Xenbase
King, How proteolysis drives the cell cycle. 1996, Pubmed
King, A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. 1995, Pubmed , Xenbase
Kornitzer, Modes of regulation of ubiquitin-mediated protein degradation. 2000, Pubmed
Kroll, Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. 1998, Pubmed , Xenbase
Kubota, Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. 1995, Pubmed , Xenbase
Kumagai, 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. 1998, Pubmed , Xenbase
Kumagai, Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. 1999, Pubmed , Xenbase
Kumagai, The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. 1998, Pubmed , Xenbase
Kumagai, The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. 1991, Pubmed , Xenbase
Kumagai, Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. 1996, Pubmed , Xenbase
Kurth, A cell cycle arrest is necessary for bottle cell formation in the early Xenopus gastrula: integrating cell shape change, local mitotic control and mesodermal patterning. 2005, Pubmed , Xenbase
Leatherwood, Emerging mechanisms of eukaryotic DNA replication initiation. 1998, Pubmed
Lei, Initiating DNA synthesis: from recruiting to activating the MCM complex. 2001, Pubmed
Lin, Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2. 2006, Pubmed , Xenbase
Lohka, Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs. 1984, Pubmed , Xenbase
Lohka, Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. 1988, Pubmed , Xenbase
Lutzmann, A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus. 2006, Pubmed , Xenbase
Madine, MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. 1995, Pubmed , Xenbase
Madine, Geminin bans replication licence. 2001, Pubmed , Xenbase
Masui, Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. 1971, Pubmed
Matten, Positive feedback between MAP kinase and Mos during Xenopus oocyte maturation. 1996, Pubmed , Xenbase
McGarry, Geminin, an inhibitor of DNA replication, is degraded during mitosis. 1998, Pubmed , Xenbase
Millar, The cdc25 M-phase inducer: an unconventional protein phosphatase. 1992, Pubmed
Mimura, Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. 1998, Pubmed , Xenbase
Mueller, Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. 1995, Pubmed , Xenbase
Mueller, Cell cycle regulation of a Xenopus Wee1-like kinase. 1995, Pubmed , Xenbase
Murray, Cyclin synthesis drives the early embryonic cell cycle. 1989, Pubmed , Xenbase
Murray, The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. 1989, Pubmed , Xenbase
Nakajo, Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes. 1999, Pubmed , Xenbase
Nebreda, Regulation of the meiotic cell cycle in oocytes. 2000, Pubmed , Xenbase
Nebreda, Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes. 1995, Pubmed , Xenbase
Nebreda, The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs. 1993, Pubmed , Xenbase
Newlon, Putting it all together: building a prereplicative complex. 1997, Pubmed , Xenbase
Newport, A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. 1982, Pubmed , Xenbase
Newport, A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. 1982, Pubmed , Xenbase
Nigg, The substrates of the cdc2 kinase. 1991, Pubmed
Nigg, Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation. 1996, Pubmed , Xenbase
Nishiyama, Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs. 2007, Pubmed , Xenbase
Nishizawa, Degradation of Mos by the N-terminal proline (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos. 1993, Pubmed , Xenbase
Ohnuma, p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. 1999, Pubmed , Xenbase
Ohnuma, Cell cycle and cell fate in the nervous system. 2001, Pubmed
Pagano, Cyclin A is required at two points in the human cell cycle. 1992, Pubmed
Palmer, A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. 1998, Pubmed , Xenbase
Peters, Subunits and substrates of the anaphase-promoting complex. 1999, Pubmed
Pfleger, The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. 2000, Pubmed , Xenbase
Philpott, E2F and its developmental regulation in Xenopus laevis. 1994, Pubmed , Xenbase
Philpott, Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin. 1991, Pubmed , Xenbase
Posada, Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. 1993, Pubmed , Xenbase
Posada, Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts. 1991, Pubmed , Xenbase
Reimann, Emi1 is required for cytostatic factor arrest in vertebrate eggs. 2002, Pubmed , Xenbase
Reimann, Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. 2001, Pubmed , Xenbase
Rempel, Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase. 1995, Pubmed , Xenbase
Romanowski, The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. 1996, Pubmed , Xenbase
Romanowski, XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. 1996, Pubmed , Xenbase
Rowles, Interaction between the origin recognition complex and the replication licensing system in Xenopus. 1996, Pubmed , Xenbase
Russo, Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. 1996, Pubmed
Sagata, Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. 1988, Pubmed , Xenbase
Sagata, What does Mos do in oocytes and somatic cells? 1997, Pubmed , Xenbase
Sagata, The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation. 1989, Pubmed , Xenbase
Schmidt, Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. 2005, Pubmed , Xenbase
Schmidt, Cytostatic factor: an activity that puts the cell cycle on hold. 2006, Pubmed , Xenbase
Schwab, Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation. 2001, Pubmed , Xenbase
Sclafani, Chromosomes in the Rocky Mountains. Yeast chromosome structure, replication and segregation, Snowmass, CO, USA, 8-13 August 1998. 1998, Pubmed
Sheets, Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation. 1995, Pubmed , Xenbase
Shibuya, Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells. 1993, Pubmed , Xenbase
Shou, Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases. 1996, Pubmed , Xenbase
Solomon, The function(s) of CAK, the p34cdc2-activating kinase. 1994, Pubmed
Stack, Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle. 1997, Pubmed , Xenbase
Strausfeld, Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. 1991, Pubmed
Stukenberg, Systematic identification of mitotic phosphoproteins. 1997, Pubmed , Xenbase
Su, Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1. 1995, Pubmed , Xenbase
Sudakin, The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. 1995, Pubmed
Suzuki, Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis. 2000, Pubmed , Xenbase
Tada, The replication licensing system. 1998, Pubmed , Xenbase
Tada, Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. 2001, Pubmed , Xenbase
Taieb, Activation of the anaphase-promoting complex and degradation of cyclin B is not required for progression from Meiosis I to II in Xenopus oocytes. 2001, Pubmed , Xenbase
Takizawa, Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. 2000, Pubmed , Xenbase
Tunquist, Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs. 2003, Pubmed , Xenbase
Vernon, A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus. 2003, Pubmed , Xenbase
Vernon, The developmental expression of cell cycle regulators in Xenopus laevis. 2003, Pubmed , Xenbase
Vernon, The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. 2003, Pubmed , Xenbase
Vernon, Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons. 2006, Pubmed , Xenbase
Waga, Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. 1994, Pubmed
Waga, The DNA replication fork in eukaryotic cells. 1998, Pubmed
Walker, Role for cyclin A in the dependence of mitosis on completion of DNA replication. 1991, Pubmed , Xenbase
Walter, Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. 2000, Pubmed , Xenbase
Walter, Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. 2000, Pubmed , Xenbase
Wohlschlegel, Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. 2000, Pubmed , Xenbase
Wohlschlegel, Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. 2002, Pubmed , Xenbase
Yew, Meiotic initiation by the mos protein in Xenopus. 1992, Pubmed , Xenbase
You, Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication. 2002, Pubmed , Xenbase
Yu, Identification of a cullin homology region in a subunit of the anaphase-promoting complex. 1998, Pubmed
Zachariae, Whose end is destruction: cell division and the anaphase-promoting complex. 1999, Pubmed
Zou, Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. 1999, Pubmed , Xenbase