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The satellite symposium on 'Making and breaking the left-right axis: implications of laterality in development and disease' was held in June 2013 in conjunction with the 17th International Society for Developmental Biology meeting in Cancún, Mexico. As we summarize here, leaders in the field gathered at the symposium to discuss recent advances in understanding how left-right asymmetry is generated and utilized across the animal kingdom.
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A human syndrome caused by immotile cilia.
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A human syndrome caused by immotile cilia.
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Caspary,
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Pubmed
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Xenbase
Cui,
Rotation of organizer tissue contributes to left-right asymmetry.
2009,
Pubmed
Davis,
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Pubmed
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Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
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Pubmed
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2009,
Pubmed
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Xenbase
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2013,
Pubmed
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2003,
Pubmed
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Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry.
2011,
Pubmed
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Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.
2012,
Pubmed
Lenhart,
Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry.
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Pubmed
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2004,
Pubmed
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Pubmed
McGrath,
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Pubmed
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Pubmed
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Pubmed
Peterson,
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Pubmed
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DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
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Pubmed
Pierpont,
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Chiral forces organize left-right patterning in C. elegans by uncoupling midline and anteroposterior axis.
2010,
Pubmed
Ramsdell,
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Pubmed
Schumacher,
Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans.
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Schweickert,
Cilia-driven leftward flow determines laterality in Xenopus.
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Pubmed
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Xenbase
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2005,
Pubmed
Shinohara,
Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.
2012,
Pubmed
Thompson,
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2012,
Pubmed
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Xenbase
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A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.
2013,
Pubmed
Vermot,
Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos.
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Pubmed
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Rere controls retinoic acid signalling and somite bilateral symmetry.
2010,
Pubmed
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Role of the gut endoderm in relaying left-right patterning in mice.
2012,
Pubmed
Walentek,
ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development.
2012,
Pubmed
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Xenbase
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Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult.
2012,
Pubmed
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Mechanisms of left-right asymmetry: what's right and what's left?
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Pubmed
Yuan,
Congenital heart disease: emerging themes linking genetics and development.
2013,
Pubmed
Zhao,
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2013,
Pubmed