Biochem Biophys Res Commun 1990 Jan 15;1661:380-6.

Formation of inositol pentakisphosphate by ovarian follicles of Xenopus laevis from metabolism of inositol (1,4,5)trisphosphate and inositol (1,3,4,5)tetrakisphosphate and from receptor activation.

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Small amounts of a higher inositol phosphate with chromatographic properties of [3H]inositol (1,3,4,5,6)pentakisphosphate were formed from [3H]inositol (1,4,5)trisphosphate added to homogenates of ovarian follicles of Xenopus laevis, and from [3H]inositol (1,3,4,5)tetrakisphosphate after injection into follicular oocytes. Other intermediate forms of inositol tetrakisphosphate were not detectable. [3H]inositol (1,3,4,5,6)pentakisphosphate prepared from chicken erythrocytes was metabolized in homogenates to an inositol tetrakisphosphate eluting later than the (1,3,4,5) isomer. Activation of receptors in ovarian follicles of Xenopus laevis with acetylcholine or stimulation with injected GTP gamma S caused formation not only of inositol trisphosphate and its expected metabolites but also of small amounts of inositol pentakisphosphate. These results suggest that the latter may be formed from metabolites of inositol (1,4,5)trisphosphate in this tissue during receptor activation.

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