XB-ART-56051
Immunol Invest
2019 Oct 01;487:737-758. doi: 10.1080/08820139.2019.1631341.
Show Gene links
Show Anatomy links
Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer.
Banach M
,
Robert J
.
???displayArticle.abstract???
Cancers impose a significant health and economic burden. By harnessing the immune system, current immunotherapies have revolutionized the treatment against human cancers and potentially offer a long-term cure. Among others, innate-like T (iT) cells, including natural killer T cells, are promising candidates for immunotherapies. Unlike conventional T cells, iT cells regulate multiple immune processes and express an invariant T cell receptor that is shared among different individuals. However, the conditions that activate the pro- and antitumor functions of iT cells are partially understood. These gaps in knowledge hamper the use of iT cell in clinics. It might be beneficial to examine the roles of iT cells in an alternative animal model - the amphibian Xenopus whose immune system shares many similarities to that of mammals. Here, we review the iT cell biology in the context of mammalian cancers and discuss the challenges currently found in the field. Next, we introduce the advantages of Xenopus as a model to investigate the role of iT cells and interacting major histocompatibility complex (MHC) class I-like molecules in tumor immunity. In Xenopus, 2 specific iT cell subsets, Vα6 and Vα22 iT cells, recognize and fight tumor cells. Furthermore, our recent data reveal the complex functions of the Xenopus MHC class I-like (XNC) gene XNC10 in tumor immune responses. By utilizing reverse genetics, transgenesis, and MHC tetramers, we have a unique opportunity to uncover the relevance of XNC genes and iT cell in Xenopus tumor immunity.
???displayArticle.pubmedLink??? 31223047
???displayArticle.pmcLink??? PMC6699903
???displayArticle.link??? Immunol Invest
???displayArticle.grants??? [+]
Species referenced: Xenopus laevis
Genes referenced: myh4 tnfrsf10b
References [+] :
Adams,
The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
2013, Pubmed
Adams, The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules. 2013, Pubmed
Bagchi, CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma. 2016, Pubmed
Banach, Exploring the functions of nonclassical MHC class Ib genes in Xenopus laevis by the CRISPR/Cas9 system. 2017, Pubmed , Xenbase
Bedel, Lower TCR repertoire diversity in Traj18-deficient mice. 2012, Pubmed
Bendelac, The biology of NKT cells. 2007, Pubmed
Berzins, Presumed guilty: natural killer T cell defects and human disease. 2011, Pubmed
Berzins, Natural killer T cells: drivers or passengers in preventing human disease? 2014, Pubmed
Berzins, Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies. 2004, Pubmed
Biswas, Metabolic Reprogramming of Immune Cells in Cancer Progression. 2015, Pubmed
Bjordahl, iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. 2012, Pubmed
Bjorkman, Structure of the human class I histocompatibility antigen, HLA-A2. , Pubmed
Bojarska-Junak, CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis. 2014, Pubmed
Bonish, Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells. 2000, Pubmed
Bradbury, Mouse CD1 is distinct from and co-exists with TL in the same thymus. 1988, Pubmed
Braud, HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. 1998, Pubmed
Bricard, Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors. 2009, Pubmed
Brossay, Mouse CD1 is mainly expressed on hemopoietic-derived cells. 1997, Pubmed
Brossay, CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. 1998, Pubmed
Brutkiewicz, CD1d ligands: the good, the bad, and the ugly. 2006, Pubmed
Chang, HLA class I defects in malignant lesions: what have we learned? 2003, Pubmed
Chong, CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival. 2015, Pubmed
Coquet, Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. 2008, Pubmed
Crowe, A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. 2002, Pubmed
Crowe, Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. 2003, Pubmed
Cui, Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. 1997, Pubmed
Dascher, Evolutionary biology of CD1. 2007, Pubmed
Dhodapkar, Type II NKT Cells and Their Emerging Role in Health and Disease. 2017, Pubmed
Doolittle, Convergent evolution: the need to be explicit. 1994, Pubmed
Edholm, Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus. 2018, Pubmed , Xenbase
Edholm, Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians. 2013, Pubmed , Xenbase
Edholm, Unusual evolutionary conservation and further species-specific adaptations of a large family of nonclassical MHC class Ib genes across different degrees of genome ploidy in the amphibian subfamily Xenopodinae. 2014, Pubmed , Xenbase
Edholm, Nonclassical MHC-Restricted Invariant Vα6 T Cells Are Critical for Efficient Early Innate Antiviral Immunity in the Amphibian Xenopus laevis. 2015, Pubmed , Xenbase
Edholm, Evolution of innate-like T cells and their selection by MHC class I-like molecules. 2016, Pubmed , Xenbase
Edholm, Critical Role of an MHC Class I-Like/Innate-Like T Cell Immune Surveillance System in Host Defense against Ranavirus (Frog Virus 3) Infection. 2019, Pubmed , Xenbase
Exley, A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. 2001, Pubmed
Farkona, Cancer immunotherapy: the beginning of the end of cancer? 2016, Pubmed
Flajnik, Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis. 1986, Pubmed , Xenbase
Flajnik, A cold-blooded view of adaptive immunity. 2018, Pubmed
Flajnik, A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus. 1993, Pubmed , Xenbase
Garcia-Lora, MHC class I antigens, immune surveillance, and tumor immune escape. 2003, Pubmed
Gleimer, Stress management: MHC class I and class I-like molecules as reporters of cellular stress. 2003, Pubmed
Godfrey, Raising the NKT cell family. 2010, Pubmed
Godfrey, Unconventional T Cell Targets for Cancer Immunotherapy. 2018, Pubmed
Gorini, Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis. 2017, Pubmed
Goyos, Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian species. 2011, Pubmed , Xenbase
Goyos, Involvement of nonclassical MHC class Ib molecules in heat shock protein-mediated anti-tumor responses. 2007, Pubmed , Xenbase
Grayfer, Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver. 2013, Pubmed , Xenbase
Guselnikov, The amphibians Xenopus laevis and Silurana tropicalis possess a family of activating KIR-related Immunoglobulin-like receptors. 2010, Pubmed , Xenbase
Guselnikov, The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution. 2008, Pubmed , Xenbase
Gyorffy, Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. 2012, Pubmed
Györffy, An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. 2010, Pubmed
Győrffy, Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer. 2013, Pubmed
Hadji-Azimi, Atlas of adult Xenopus laevis laevis hematology. 1987, Pubmed , Xenbase
Haynes-Gilmore, A critical role of non-classical MHC in tumor immune evasion in the amphibian Xenopus model. 2014, Pubmed , Xenbase
Haynes-Gimore, Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration. 2015, Pubmed , Xenbase
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Holzapfel, Antigen-dependent versus -independent activation of invariant NKT cells during infection. 2014, Pubmed
Horton, T-cell and natural killer cell development in thymectomized Xenopus. 1998, Pubmed , Xenbase
Jiang, Mechanism of NKT cell-mediated transplant tolerance. 2007, Pubmed
Kawano, CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. 1997, Pubmed
Kitamura, The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. 1999, Pubmed
Kobayashi, KRN7000, a novel immunomodulator, and its antitumor activities. 1995, Pubmed
Kochan, Role of non-classical MHC class I molecules in cancer immunosuppression. 2013, Pubmed
Lepore, A novel self-lipid antigen targets human T cells against CD1c(+) leukemias. 2014, Pubmed
Lin, Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy. 2015, Pubmed
Liu, Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma. 2017, Pubmed
Mattarollo, Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production. 2010, Pubmed
McEwen-Smith, The regulatory role of invariant NKT cells in tumor immunity. 2015, Pubmed
Menyhárt, Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. 2018, Pubmed
Michot, Immune-related adverse events with immune checkpoint blockade: a comprehensive review. 2016, Pubmed
Miller, Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family. 2005, Pubmed
Moody, CD1: From Molecules to Diseases. 2017, Pubmed
Naert, CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis. 2016, Pubmed , Xenbase
Nair, Natural Killer T Cells in Cancer Immunotherapy. 2017, Pubmed
Ohta, Ancestral organization of the MHC revealed in the amphibian Xenopus. 2006, Pubmed , Xenbase
Ohta, Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates. 2015, Pubmed , Xenbase
Ostrand-Rosenberg, Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent. 2002, Pubmed
Pardoll, The blockade of immune checkpoints in cancer immunotherapy. 2012, Pubmed
Pellicci, A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. 2002, Pubmed
Pilones, Invariant NKT cells as novel targets for immunotherapy in solid tumors. 2012, Pubmed
Porcelli, The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. 1999, Pubmed
Reilly, Cytokine dependent and independent iNKT cell activation. 2010, Pubmed
Renukaradhya, Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. 2006, Pubmed
Robert, Lymphoid tumors of Xenopus laevis with different capacities for growth in larvae and adults. 1994, Pubmed , Xenbase
Robert, A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles. 2014, Pubmed , Xenbase
Robert, Ontogeny of the alloimmune response against a transplanted tumor in Xenopus laevis. 1995, Pubmed , Xenbase
Robert, Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates. 2010, Pubmed
Robert, Evolution of immune surveillance and tumor immunity: studies in Xenopus. 1998, Pubmed , Xenbase
Robert, Comparative and developmental study of the immune system in Xenopus. 2009, Pubmed , Xenbase
Robertson, NKT cell networks in the regulation of tumor immunity. 2014, Pubmed
Rodgers, MHC class Ib molecules bridge innate and acquired immunity. 2005, Pubmed
Rogers, Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems. 2016, Pubmed
Rossjohn, Recognition of CD1d-restricted antigens by natural killer T cells. 2012, Pubmed
Salomonsen, Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC. 2005, Pubmed
Salter-Cid, Expression of MHC class Ia and class Ib during ontogeny: high expression in epithelia and coregulation of class Ia and lmp7 genes. 1998, Pubmed , Xenbase
Sammut, Axolotl MHC architecture and polymorphism. 1999, Pubmed , Xenbase
Scott-Browne, Evolutionarily conserved features contribute to αβ T cell receptor specificity. 2011, Pubmed
Seino, Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. 2001, Pubmed
Session, Genome evolution in the allotetraploid frog Xenopus laevis. 2016, Pubmed , Xenbase
Sharma, Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. 2011, Pubmed
Sonoda, Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. 2002, Pubmed
Spada, Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. 2000, Pubmed
Sriram, Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells. 2002, Pubmed
Star, The genome sequence of Atlantic cod reveals a unique immune system. 2011, Pubmed
Stern, Pancreatic carcinoma in an African clawed frog (Xenopus laevis). 2014, Pubmed , Xenbase
Stetson, Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. 2003, Pubmed
Subleski, The split personality of NKT cells in malignancy, autoimmune and allergic disorders. 2011, Pubmed
Szász, Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. 2016, Pubmed
Tandon, Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling. 2017, Pubmed , Xenbase
Terabe, CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta. 2006, Pubmed
Terabe, The role of NKT cells in tumor immunity. 2008, Pubmed
Teyton, New Directions for Natural Killer T Cells in the Immunotherapy of Cancer. 2017, Pubmed
Vance, Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). 1998, Pubmed
Van Nieuwenhuysen, TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis. 2015, Pubmed , Xenbase
Vivier, Targeting natural killer cells and natural killer T cells in cancer. 2012, Pubmed
Wang, Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells. 2018, Pubmed
Yang, Analysis of the reptile CD1 genes: evolutionary implications. 2015, Pubmed
Yoder, The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities. 2011, Pubmed
Zimmer, Clinical and immunological aspects of HLA class I deficiency. 2005, Pubmed