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The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.
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Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions about the relationship among the three molecules and their roles in different cell-cell adhesive junctions. We have found that antibodies against the Drosophila segment polarity gene armadillo cross react with a conserved vertebrate protein. This protein is membrane associated, probably via its interaction with a cadherin-like molecule. This cross-reacting protein is the cadherin-associated protein beta-catenin. Using anti-armadillo and antiplakoglobin antibodies, it was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type. Plakoglobin interacts with the desmosomal glycoprotein desmoglein I, and weakly with E-cadherin. Although beta-catenin interacts tightly with E-cadherin, it does not seem to be associated with either desmoglein I or with isolated desmosomes. Anti-armadillo antibodies have been further used to determine the intracellular localization of beta-catenin, and to examine its tissue distribution. The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed.
Amagai,
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.
1991, Pubmed
Amagai,
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion.
1991,
Pubmed
Angst,
Desmoplakin II expression is not restricted to stratified epithelia.
1990,
Pubmed
Blaschuk,
Purification of desmoglein II: a method for the preparation and fractionation of desmosomal components.
1986,
Pubmed
Choi,
Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm.
1989,
Pubmed
,
Xenbase
Choi,
A cadherin-like protein in eggs and cleaving embryos of Xenopus laevis is expressed in oocytes in response to progesterone.
1990,
Pubmed
,
Xenbase
Collins,
Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains.
1991,
Pubmed
Cowin,
Plakoglobin: a protein common to different kinds of intercellular adhering junctions.
1986,
Pubmed
Franke,
Immunolocalization of plakoglobin in endothelial junctions: identification as a special type of Zonulae adhaerentes.
1987,
Pubmed
Franke,
Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.
1989,
Pubmed
Goodwin,
Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules.
1990,
Pubmed
Gorbsky,
Isolation of the non-glycosylated proteins of desmosomes and immunolocalization of a third plaque protein: desmoplakin III.
1985,
Pubmed
Green,
Structure of the human desmoplakins. Implications for function in the desmosomal plaque.
1990,
Pubmed
Gumbiner,
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.
1986,
Pubmed
Hatta,
Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family.
1988,
Pubmed
Herrenknecht,
The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.
1991,
Pubmed
,
Xenbase
Jones,
Intermediate filament-plasma membrane interactions.
1991,
Pubmed
Jones,
Characterization of a 125K glycoprotein associated with bovine epithelial desmosomes.
1988,
Pubmed
Kapprell,
Biochemical characterization of the soluble form of the junctional plaque protein, plakoglobin, from different cell types.
1987,
Pubmed
Kemler,
Uvomorulin-catenin complex: cytoplasmic anchorage of a Ca2+-dependent cell adhesion molecule.
1989,
Pubmed
Koch,
Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules.
1990,
Pubmed
Korman,
Demonstration of an adhering-junction molecule (plakoglobin) in the autoantigens of pemphigus foliaceus and pemphigus vulgaris.
1989,
Pubmed
Magee,
Transmembrane molecular assemblies regulated by the greater cadherin family.
1991,
Pubmed
Mattey,
Calcium-induced desmosome formation in cultured kidney epithelial cells.
1986,
Pubmed
McCrea,
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.
1991,
Pubmed
,
Xenbase
McCrea,
Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure.
1991,
Pubmed
,
Xenbase
McMahon,
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis.
1989,
Pubmed
,
Xenbase
McMahon,
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
1990,
Pubmed
Mechanic,
Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules.
1991,
Pubmed
Nagafuchi,
Cell binding function of E-cadherin is regulated by the cytoplasmic domain.
1988,
Pubmed
Nagafuchi,
The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.
1991,
Pubmed
Nagafuchi,
Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.
1989,
Pubmed
Nilles,
Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome.
1991,
Pubmed
Ozawa,
Molecular organization of the uvomorulin-catenin complex.
1992,
Pubmed
Ozawa,
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
1989,
Pubmed
Parker,
Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing.
1991,
Pubmed
Pasdar,
Regulation of desmosome assembly in epithelial cells: kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain.
1989,
Pubmed
Pasdar,
Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain assembly at the plasma membrane.
1991,
Pubmed
Peifer,
The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation.
1991,
Pubmed
Peifer,
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.
1990,
Pubmed
Peyriéras,
Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin.
1985,
Pubmed
Resh,
Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules.
1985,
Pubmed
Riggleman,
Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless.
1990,
Pubmed
Schwarz,
Desmosomes and hemidesmosomes: constitutive molecular components.
1990,
Pubmed
Stappenbeck,
The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells.
1992,
Pubmed
Suzuki,
Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.
1991,
Pubmed
Takeichi,
Cadherin cell adhesion receptors as a morphogenetic regulator.
1991,
Pubmed
Thomas,
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
1990,
Pubmed
Wheeler,
Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.
1991,
Pubmed
Wheelock,
N-cadherin-associated proteins in chicken muscle.
1991,
Pubmed
Wieschaus,
Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis.
1987,
Pubmed
