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Rouxs Arch Dev Biol
1995 Nov 01;2053-4:198-202. doi: 10.1007/BF00357766.
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Cardiac myogenesis: overexpression of XCsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of XMHCα gene.
Fu Y
,
Izumo S
.
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XCsx2, a homeobox-containing gene, is expressed in cardiac muscle during Xenopus development, while the XMEF2A gene is expressed in both cardiac and skeletal muscle. Microinjection of either XCsx2 or XMEF2A mRNA into single blastomeres of two-cell stage Xenopus embryos induced precocious expression of the myosin heavy-chain alpha (XMHCα) gene at the neural plate stage (stage 14). Co-injection of both XCsx2 and XMEF2A mRNAs induced still earlier expression at the late gastrula stage (stage 12). These changes were evident in whole embryos but not in animal pole explants from injected embryos. Overexpression of XCsx2 or XMEF2A also caused an enlarged heart and abnormalities of notochord and tail in Xenopus embryos. These findings suggest that both XCsx2 and XMEF2A transcription factors have an important role in regulating the expression of the XMHCα gene and the morphogenesis of hearttissue in Xenopus development.
Azpiazu,
tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.
1993, Pubmed
Azpiazu,
tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.
1993,
Pubmed
Bodmer,
The gene tinman is required for specification of the heart and visceral muscles in Drosophila.
1993,
Pubmed
Bodmer,
Heart development in Drosophila and its relationship to vertebrates.
1995,
Pubmed
Breitbart,
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.
1993,
Pubmed
,
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Chambers,
The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos.
1994,
Pubmed
,
Xenbase
Chambers,
Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis.
1992,
Pubmed
,
Xenbase
Drysdale,
Cardiac troponin I is a heart-specific marker in the Xenopus embryo: expression during abnormal heart morphogenesis.
1994,
Pubmed
,
Xenbase
Edmondson,
Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis.
1994,
Pubmed
Fu,
Expression of circular and linearized bacterial chloramphenicol acetyltransferase genes with or without viral promoters after injection into fertilized eggs, unfertilized eggs and oocytes ofXenopus laevis.
1989,
Pubmed
,
Xenbase
Komuro,
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
1993,
Pubmed
Krieg,
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.
1984,
Pubmed
,
Xenbase
Leifer,
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.
1993,
Pubmed
Lints,
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
1993,
Pubmed
Logan,
Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos.
1993,
Pubmed
,
Xenbase
Ludolph,
Overexpression of XMyoD or XMyf5 in Xenopus embryos induces the formation of enlarged myotomes through recruitment of cells of nonsomitic lineage.
1994,
Pubmed
,
Xenbase
Martin,
Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.
1993,
Pubmed
Martin,
A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.
1994,
Pubmed
McDermott,
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
1993,
Pubmed
McGinnis,
A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
1984,
Pubmed
Peng,
Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols.
1991,
Pubmed
,
Xenbase
Pollock,
Human SRF-related proteins: DNA-binding properties and potential regulatory targets.
1991,
Pubmed
Scott,
Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.
1984,
Pubmed
Scott,
Intimations of a creature.
1994,
Pubmed
Tonissen,
XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development.
1994,
Pubmed
,
Xenbase
Yu,
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.
1992,
Pubmed
