Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Anion, cation, and zwitterion selectivity of phospholemman channel molecules.
Kowdley GC
,
Ackerman SJ
,
Chen Z
,
Szabo G
,
Jones LR
,
Moorman JR
.
???displayArticle.abstract??? Phospholemman (PLM), a 72-amino acid membrane protein with a single transmembrane domain, forms taurine-selective ion channels in lipid bilayers. Because taurine forms zwitterions, a taurine-selective channel might have binding sites for both anions and cations. Here we show that PLM channels indeed allow fluxes of both cations and anions, making instantaneous and voltage-dependent transitions among conformations with drastically different ion selectivity characteristics. This surprising and novel ion channel behavior offers a molecular explanation for selective taurine flux across cell membranes and may explain why molecules in the phospholemman family can induce cation- or anion-selective conductances when expressed in Xenopus oocytes.
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994, Pubmed,
Xenbase
Ackerman,
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Attali,
The protein IsK is a dual activator of K+ and Cl- channels.
1993,
Pubmed
,
Xenbase
Attali,
A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Hausdorff,
Functional characterization of a minimal K+ channel expressed from a synthetic gene.
1991,
Pubmed
,
Xenbase
Huxtable,
Physiological actions of taurine.
1992,
Pubmed
Jackson,
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
1993,
Pubmed
Kowdley,
Hyperpolarization-activated chloride currents in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Moorman,
Unitary anion currents through phospholemman channel molecules.
1995,
Pubmed
,
Xenbase
Moorman,
Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Morrison,
neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.
1994,
Pubmed
Morrison,
Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Palmer,
Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium.
1991,
Pubmed
Shimbo,
Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Szücs,
The volume-activated chloride current in endothelial cells from bovine pulmonary artery is not modulated by phosphorylation.
1996,
Pubmed
Tzounopoulos,
Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes.
1995,
Pubmed
,
Xenbase
Voets,
Blockers of volume-activated Cl- currents inhibit endothelial cell proliferation.
1995,
Pubmed
