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Cell
2008 Jun 27;1337:1241-54. doi: 10.1016/j.cell.2008.05.030.
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DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.
Ly A
,
Nikolaev A
,
Suresh G
,
Zheng Y
,
Tessier-Lavigne M
,
Stein E
.
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During nervous system development, spinal commissural axons project toward and across the ventral midline. They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin receptor DCC. However, previous studies suggest that additional receptor components are required. Here, we report that the Down's syndrome Cell Adhesion Molecule (DSCAM), a candidate gene implicated in the mental retardation phenotype of Down's syndrome, is expressed on spinal commissural axons, binds netrin-1, and is necessary for commissural axons to grow toward and across the midline. DSCAM and DCC can each mediate a turning response of these neurons to netrin-1. Similarly, Xenopus spinal neurons exogenously expressing DSCAM can be attracted by netrin-1 independently of DCC. These results show that DSCAM is a receptor that can mediate turning responses to netrin-1 and support a key role for netrin/DSCAM signaling in commissural axon guidance in vertebrates.
Agarwala,
Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion.
2001, Pubmed
Agarwala,
Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion.
2001,
Pubmed
Antonarakis,
The challenge of Down syndrome.
2006,
Pubmed
Barlow,
Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?
2002,
Pubmed
Charron,
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.
2003,
Pubmed
,
Xenbase
Chen,
The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.
2006,
Pubmed
Chen,
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.
2008,
Pubmed
Colamarino,
The role of the floor plate in axon guidance.
1995,
Pubmed
Dickson,
Molecular mechanisms of axon guidance.
2002,
Pubmed
Ding,
Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.
2005,
Pubmed
Fazeli,
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
1997,
Pubmed
Fuerst,
Neurite arborization and mosaic spacing in the mouse retina require DSCAM.
2008,
Pubmed
Hughes,
Homophilic Dscam interactions control complex dendrite morphogenesis.
2007,
Pubmed
Keino-Masu,
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
1996,
Pubmed
Kennedy,
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.
1994,
Pubmed
Matthews,
Dendrite self-avoidance is controlled by Dscam.
2007,
Pubmed
Meijers,
Structural basis of Dscam isoform specificity.
2007,
Pubmed
Millard,
Dscam2 mediates axonal tiling in the Drosophila visual system.
2007,
Pubmed
Ming,
cAMP-dependent growth cone guidance by netrin-1.
1997,
Pubmed
,
Xenbase
Okada,
Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
2006,
Pubmed
Osumi,
Gene transfer into cultured mammalian embryos by electroporation.
2001,
Pubmed
Placzek,
Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant.
1990,
Pubmed
Schmucker,
Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.
2000,
Pubmed
Serafini,
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.
1994,
Pubmed
Serafini,
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.
1996,
Pubmed
Soba,
Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.
2007,
Pubmed
Stein,
RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.
2001,
Pubmed
,
Xenbase
Stein,
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation.
2001,
Pubmed
,
Xenbase
Tessier-Lavigne,
Chemotropic guidance of developing axons in the mammalian central nervous system.
,
Pubmed
Yamagata,
Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina.
2008,
Pubmed
Yamakawa,
DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.
1998,
Pubmed
Yu,
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function.
2002,
Pubmed
Zhan,
Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies.
2004,
Pubmed
Zhu,
Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe.
2006,
Pubmed
Zipursky,
Got diversity? Wiring the fly brain with Dscam.
2006,
Pubmed
