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Early effects of aldosterone on the basolateral potassium conductance of A6 cells.
Broillet MC
,
Berger A
,
Horisberger JD
.
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Aldosterone increases the basolateral conductance in target epithelia. The basolateral membrane of tight epithelia contains two different types of K+ conductances (GK), a "resting" and a volume-activated GK. We have studied the early effects (at 4 hours) of 500 nmol/l aldosterone on the basolateral membrane GK of A6 cells (a Xenopus laevis kidney cell line), after the permeabilization of the apical membrane with amphotericin B. In the presence of a 97 to 3 mmol/l apical to basolateral K+ gradient, the "resting", inward rectifying GK was similar in control and aldosterone treated cells. In contrast, aldosterone induced a 2-fold increase of the volume-activated quinidine sensitive GK.
Broillet,
Basolateral membrane potassium conductance of A6 cells.
1991,
Pubmed
,
Xenbase
Garty,
Mechanisms of aldosterone action in tight epithelia.
1986,
Pubmed
Horisberger,
Early effects of aldosterone on apical and basolateral membrane conductances of TBM cells.
1992,
Pubmed
Hurst,
Apical K+ channels of frog diluting segment: inhibition by acidification.
1989,
Pubmed
Illek,
Aldosterone regulation of basolateral potassium channels in alveolar epithelium.
1990,
Pubmed
,
Xenbase
Koeppen,
Intracellular microelectrode characterization of the rabbit cortical collecting duct.
1983,
Pubmed
Nagel,
Mechanism of action of aldosterone on active sodium transport across toad skin.
1980,
Pubmed
Oberleithner,
Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney.
1987,
Pubmed
Petzel,
Correlates of aldosterone-induced increases in Cai2+ and Isc suggest that Cai2+ is the second messenger for stimulation of apical membrane conductance.
1992,
Pubmed
,
Xenbase
Preston,
Dexamethasone accelerates differentiation of A6 epithelia and increases response to vasopressin.
1988,
Pubmed
,
Xenbase
Verrey,
Regulation by aldosterone of Na+,K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells.
1987,
Pubmed
,
Xenbase
Wang,
Mechanism of aldosterone-induced increase of K+ conductance in early distal renal tubule cells of the frog.
1989,
Pubmed
