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XB-ART-11979
Mech Dev 1999 Dec 01;891-2:179-83. doi: 10.1016/s0925-4773(99)00206-3.
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Expression of Frzb-1 during chick development.

Duprez D , Leyns L , Bonnin MA , Lapointe F , Etchevers H , De Robertis EM , Le Douarin N .


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We cloned the chick homolog of Xenopus and mouse Frzb-1, a secreted Wnt antagonist and performed in situ hybridizations to determine the pattern of cFrzb-1 expression in the developing chick embryo. At early stages, cFrzb-1 transcripts are located exclusively in the ectodermal layer corresponding to the neural plate. The labelling continues in the neural tube, but is always excluded from the floor plate. cFrzb-1 mRNA is expressed by migrating cephalic and truncal neural crest cells. Later, cFrzb-1 transcripts are found in a subset of neural crest derivatives such as cephalic cartilage, nerves and spinal ganglia. In addition to ectodermal derivatives, cFrzb-1 transcripts were also observed in mesodermal derivatives such as vertebral and limb cartilage, the adrenal cortex, the gonads, and a subpopulation of blood cells.

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Species referenced: Xenopus
Genes referenced: frzb