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EMBO Rep
2001 Nov 01;211:1047-51. doi: 10.1093/embo-reports/kve232.
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The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl- concentration.
König J
,
Schreiber R
,
Voelcker T
,
Mall M
,
Kunzelmann K
.
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Activation of the CFTR Cl- channel inhibits epithelial Na+ channels (ENaC), according to studies on epithelial cells and overexpressing recombinant cells. Here we demonstrate that ENaC is inhibited during stimulation of the cystic fibrosis transmembrance conductance regulator (CFTR) in Xenopus oocytes, independent of the experimental set-up and the magnitude of the whole-cell current. Inhibition of ENaC is augmented at higher CFTR Cl- currents. Similar to CFTR, ClC-0 Cl- currents also inhibit ENaC, as well as high extracellular Na+ and Cl- in partially permeabilized oocytes. Thus, inhibition of ENaC is not specific to CFTR and seems to be mediated by Cl-.
Boucher,
Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures.
1988, Pubmed
Boucher,
Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures.
1988,
Pubmed
Briel,
Cl- transport by cystic fibrosis transmembrane conductance regulator (CFTR) contributes to the inhibition of epithelial Na+ channels (ENaCs) in Xenopus oocytes co-expressing CFTR and ENaC.
1998,
Pubmed
,
Xenbase
Hübner,
Feedback inhibition of epithelial Na(+) channels in Xenopus oocytes does not require G(0) or G(i2) proteins.
1999,
Pubmed
,
Xenbase
Ismailov,
Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator.
1996,
Pubmed
Ji,
The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel.
2000,
Pubmed
,
Xenbase
Jiang,
Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes.
2000,
Pubmed
,
Xenbase
Kellenberger,
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.
1998,
Pubmed
,
Xenbase
Kieferle,
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
1994,
Pubmed
Kunzelmann,
Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator.
1997,
Pubmed
,
Xenbase
Letz,
cAMP stimulates CFTR-like Cl- channels and inhibits amiloride-sensitive Na+ channels in mouse CCD cells.
1997,
Pubmed
Mall,
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
1998,
Pubmed
Mall,
Inhibition of amiloride-sensitive epithelial Na(+) absorption by extracellular nucleotides in human normal and cystic fibrosis airways.
2000,
Pubmed
Mall,
Wild type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes.
1996,
Pubmed
,
Xenbase
Mall,
CFTR-mediated inhibition of epithelial Na+ conductance in human colon is defective in cystic fibrosis.
1999,
Pubmed
Mall,
Defective cholinergic Cl(-) secretion and detection of K(+) secretion in rectal biopsies from cystic fibrosis patients.
2000,
Pubmed
Nagel,
Non-specific activation of the epithelial sodium channel by the CFTR chloride channel.
2001,
Pubmed
,
Xenbase
Rae,
Low access resistance perforated patch recordings using amphotericin B.
1991,
Pubmed
Reddy,
Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function.
1999,
Pubmed
Reddy,
Intracellular Cl activity: evidence of dual mechanisms of cl absorption in sweat duct.
1994,
Pubmed
Schreiber,
The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel.
1999,
Pubmed
,
Xenbase
Stutts,
CFTR as a cAMP-dependent regulator of sodium channels.
1995,
Pubmed
Willumsen,
Cellular Cl- transport in cultured cystic fibrosis airway epithelium.
1989,
Pubmed
Willumsen,
Intracellular Cl- activity and cellular Cl- pathways in cultured human airway epithelium.
1989,
Pubmed
