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XB-ART-25038
Nature 1991 Feb 28;3496312:760-5. doi: 10.1038/349760a0.
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Sequence and expression of a metabotropic glutamate receptor.

Masu M , Tanabe Y , Tsuchida K , Shigemoto R , Nakanishi S .


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The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

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