Flagg TP , Yoo D , Sciortino CM , Tate M , Romero MF , Welling PA .

DK 07678 NIDDK NIH HHS , DK 54231 NIDDK NIH HHS , T32 GM 08181 NIGMS NIH HHS , T32 GM008181 NIGMS NIH HHS , T32 DK007678 NIDDK NIH HHS , R01 DK054231 NIDDK NIH HHS

BARTTER, Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962, Pubmed

BARTTER, Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962, Pubmed
Chanchevalap, Involvement of histidine residues in proton sensing of ROMK1 channel. 2000, Pubmed
Choe, A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. 1997, Pubmed , Xenbase
Derst, A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels. 1998, Pubmed , Xenbase
Derst, Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function. 1997, Pubmed
Dewan, Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release. 1993, Pubmed
Drain, KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit. 1998, Pubmed , Xenbase
Enkvetchakul, The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. 2000, Pubmed
Fakler, Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH. 1996, Pubmed , Xenbase
Fanning, Protein-protein interactions: PDZ domain networks. 1996, Pubmed
Flagg, A mutation linked with Bartter's syndrome locks Kir 1.1a (ROMK1) channels in a closed state. 1999, Pubmed , Xenbase
Giebisch, Renal potassium transport: mechanisms and regulation. 1998, Pubmed
Guay-Woodford, Bartter syndrome: unraveling the pathophysiologic enigma. 1998, Pubmed
Hamill, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. 1981, Pubmed
He, Dual role of Lys206-Lys296 interaction in human transferrin N-lobe: iron-release trigger and anion-binding site. 1999, Pubmed
Ho, Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. 1993, Pubmed , Xenbase
Ho, Site-directed mutagenesis by overlap extension using the polymerase chain reaction. 1989, Pubmed
Huang, Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. 1998, Pubmed , Xenbase
Jones, Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. 2001, Pubmed
Kobe, Active site-directed protein regulation. 1999, Pubmed
Koster, ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. 1999, Pubmed
Koster, Assembly of ROMK1 (Kir 1.1a) inward rectifier K+ channel subunits involves multiple interaction sites. 1998, Pubmed , Xenbase
Krieg, Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. 1984, Pubmed , Xenbase
Leipziger, PKA site mutations of ROMK2 channels shift the pH dependence to more alkaline values. 2000, Pubmed , Xenbase
Li, Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. 1992, Pubmed
Lopatin, Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. 1994, Pubmed , Xenbase
Ma, Role of ER export signals in controlling surface potassium channel numbers. 2001, Pubmed , Xenbase
MacGregor, Partially active channels produced by PKA site mutation of the cloned renal K+ channel, ROMK2 (kir1.2). 1998, Pubmed , Xenbase
McNicholas, Regulation of ROMK1 K+ channel activity involves phosphorylation processes. 1994, Pubmed , Xenbase
McNicholas, pH-dependent modulation of the cloned renal K+ channel, ROMK. 1998, Pubmed , Xenbase
Methfessel, Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. 1986, Pubmed , Xenbase
Nichols, Inward rectifier potassium channels. 1997, Pubmed
NULL, Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome: evidence for genetic heterogeneity. International Collaborative Study Group for Bartter-like Syndromes. 1997, Pubmed
Perozo, Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. 1998, Pubmed
Qu, Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domains. 2000, Pubmed , Xenbase
Romero, Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. 2000, Pubmed , Xenbase
Romero, Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter. 1997, Pubmed , Xenbase
Schulte, K(+)-dependent gating of K(ir)1.1 channels is linked to pH gating through a conformational change in the pore. 2001, Pubmed , Xenbase
Schulte, pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini. 1998, Pubmed , Xenbase
Schulte, pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. 1999, Pubmed
Sciortino, Cation and voltage dependence of rat kidney electrogenic Na(+)-HCO(-)(3) cotransporter, rkNBC, expressed in oocytes. 1999, Pubmed , Xenbase
Shyng, Membrane phospholipid control of nucleotide sensitivity of KATP channels. 1998, Pubmed
Sigworth, Data transformations for improved display and fitting of single-channel dwell time histograms. 1987, Pubmed
Simon, Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. 1996, Pubmed
Simon, Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. 1996, Pubmed
Simon, Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. 1997, Pubmed
Tinker, Regions responsible for the assembly of inwardly rectifying potassium channels. 1996, Pubmed , Xenbase
Tsai, Intracellular H+ inhibits a cloned rat kidney outer medulla K+ channel expressed in Xenopus oocytes. 1995, Pubmed , Xenbase
Tucker, Molecular determinants of KATP channel inhibition by ATP. 1998, Pubmed , Xenbase
Tucker, Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. 1999, Pubmed
Wang, Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule. 1990, Pubmed
Welling, Primary structure and functional expression of a cortical collecting duct Kir channel. 1997, Pubmed , Xenbase
Wible, Gating of inwardly rectifying K+ channels localized to a single negatively charged residue. 1994, Pubmed , Xenbase
Wyszynski, Analysis of ion channel associated proteins. 1999, Pubmed
Xu, Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase. 1996, Pubmed , Xenbase
Yang, Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. 1995, Pubmed , Xenbase