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XB-ART-26106
Brain Res Mol Brain Res 1990 Feb 01;72:105-13. doi: 10.1016/0169-328x(90)90087-t.
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Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

Joho RH , Moorman JR , VanDongen AM , Kirsch GE , Silberberg H , Schuster G , Brown AM .


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Sodium (Na+) channels are members of a multigene family and are responsible for generation and propagation of the action potential in excitable cells. We have assembled, in a transcription-competent vector, a full-length cDNA clone encoding the rat brain type III Na+ channel. Xenopus oocytes microinjected with in vitro synthesized mRNA expressed functional rat brain Na+ channels from such 'cloned' RNA transcripts. We found that type III Na+ currents in whole cell microelectrode voltage clamp and in cell-attached patch recordings decayed much more slowly than any other reported Na+ current. In addition, we saw typical and additive effects of alpha- and beta-scorpion toxins, suggesting that the Na+ channel alpha-subunit itself contains functional and distinct toxin binding sites.

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