Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-22736
FEBS Lett 1993 Mar 22;3193:229-32.
Show Gene links Show Anatomy links

External pH regulates the slowly activating potassium current IsK expressed in Xenopus oocytes.

Yamane T , Furukawa T , Horikawa S , Hiraoka M .


???displayArticle.abstract???
A slowly activating, delayed rectifier potassium current, IsK, was expressed in Xenopus laevis oocytes by injection of cRNA transcribed from a rat kidney cDNA clone. External acidification reversibly decreased the current amplitude. The effects were concentration dependent on protons with Kd at pH approximately 5.5 and a Hill coefficient of 1.0. External acidification reduced the maximal conductance (Gmax) without affecting the activation kinetics; this effect was not dependent on membrane voltages. These data suggest that H+ ions bind to the channel with a one-to-one stoichiometry, and this binding site may be located outside of the membrane electric field.

???displayArticle.pubmedLink??? 8458414
???displayArticle.link??? FEBS Lett


Species referenced: Xenopus laevis
Genes referenced: kcne1