XB-ART-29561
Dev Biol
1984 Oct 01;1052:518-25.
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Transcription of a long, interspersed, highly repeated DNA element in Xenopus laevis.
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We have analyzed the transcription of 1723, a long, repeated DNA element that is interspersed in the genome of Xenopus laevis (B. K. Kay and I. B. Dawid (1983) J. Mol. Biol. 170, 583-596). We have detected RNA homologous to 1723 in total cellular RNA from ovaries, embryos, liver, and cultured kidney cells. Transcripts from both strands of the element are present at similar concentrations in these different RNA preparations. In oocytes, approximately 100 pairs of lampbrush chromosome loops are active in the transcription of 1723 elements. The abundance of 1723 RNA increases during embryogenesis, with the highest level reached at the tadpole stage. From cellular fractionation studies, we conclude that 1723 transcripts are largely limited to the nucleus.
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